Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803660183> ?p ?o ?g. }
- W2803660183 abstract "Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by progressive loss of lung function and poor prognosis. The so-called acute exacerbation of IPF (AE-IPF) may lead to severe hypoxemia requiring mechanical ventilation in the intensive care unit (ICU). AE-IPF shares several pathophysiological features with acute respiratory distress syndrome (ARDS), a very severe condition commonly treated in this setting. A review of the literature has been conducted to underline similarities and differences in the management of patients with AE-IPF and ARDS. During AE-IPF, diffuse alveolar damage and massive loss of aeration occurs, similar to what is observed in patients with ARDS. Differently from ARDS, no studies have yet concluded on the optimal ventilatory strategy and management in AE-IPF patients admitted to the ICU. Notwithstanding, a protective ventilation strategy with low tidal volume and low driving pressure could be recommended similarly to ARDS. The beneficial effect of high levels of positive end-expiratory pressure and prone positioning has still to be elucidated in AE-IPF patients, as well as the precise role of other types of respiratory assistance (e.g., extracorporeal membrane oxygenation) or innovative therapies (e.g., polymyxin-B direct hemoperfusion). The use of systemic drugs such as steroids or immunosuppressive agents in AE-IPF is controversial and potentially associated with an increased risk of serious adverse reactions. Common pathophysiological abnormalities and similar clinical needs suggest translating to AE-IPF the lessons learned from the management of ARDS patients. Studies focused on specific therapeutic strategies during AE-IPF are warranted." @default.
- W2803660183 created "2018-06-01" @default.
- W2803660183 creator A5003473057 @default.
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- W2803660183 date "2018-03-23" @default.
- W2803660183 modified "2023-10-18" @default.
- W2803660183 title "Acute exacerbation of idiopathic pulmonary fibrosis: lessons learned from acute respiratory distress syndrome?" @default.
- W2803660183 cites W1476289819 @default.
- W2803660183 cites W1515498465 @default.
- W2803660183 cites W1525938916 @default.
- W2803660183 cites W1701699965 @default.
- W2803660183 cites W1767417046 @default.
- W2803660183 cites W1845066193 @default.
- W2803660183 cites W1852229048 @default.
- W2803660183 cites W1881794291 @default.
- W2803660183 cites W1947430191 @default.
- W2803660183 cites W1950009848 @default.
- W2803660183 cites W1964880331 @default.
- W2803660183 cites W1974232992 @default.
- W2803660183 cites W1979552392 @default.
- W2803660183 cites W1979763767 @default.
- W2803660183 cites W1979869741 @default.
- W2803660183 cites W1984994672 @default.
- W2803660183 cites W1986021206 @default.
- W2803660183 cites W1986076498 @default.
- W2803660183 cites W1988135292 @default.
- W2803660183 cites W1992120284 @default.
- W2803660183 cites W1994240340 @default.
- W2803660183 cites W1996775001 @default.
- W2803660183 cites W2006732020 @default.
- W2803660183 cites W2007557407 @default.
- W2803660183 cites W2007750657 @default.
- W2803660183 cites W2008033295 @default.
- W2803660183 cites W2009201444 @default.
- W2803660183 cites W2016204831 @default.
- W2803660183 cites W2026390886 @default.
- W2803660183 cites W2028566119 @default.
- W2803660183 cites W2029109132 @default.
- W2803660183 cites W2031651341 @default.
- W2803660183 cites W2031701227 @default.
- W2803660183 cites W2031872886 @default.
- W2803660183 cites W2035594246 @default.
- W2803660183 cites W2036509481 @default.
- W2803660183 cites W2037145800 @default.
- W2803660183 cites W2040838979 @default.
- W2803660183 cites W2045067067 @default.
- W2803660183 cites W2048519644 @default.
- W2803660183 cites W2050851499 @default.
- W2803660183 cites W2052432963 @default.
- W2803660183 cites W2053318806 @default.
- W2803660183 cites W2054107809 @default.
- W2803660183 cites W2060760532 @default.
- W2803660183 cites W2062367242 @default.
- W2803660183 cites W2062835992 @default.
- W2803660183 cites W2071319334 @default.
- W2803660183 cites W2073517332 @default.
- W2803660183 cites W2082410582 @default.
- W2803660183 cites W2085336270 @default.
- W2803660183 cites W2085474708 @default.
- W2803660183 cites W2092101474 @default.
- W2803660183 cites W2096033564 @default.
- W2803660183 cites W2098188593 @default.
- W2803660183 cites W2099578940 @default.
- W2803660183 cites W2100891932 @default.
- W2803660183 cites W2104513111 @default.
- W2803660183 cites W2106923828 @default.
- W2803660183 cites W2111256250 @default.
- W2803660183 cites W2113752525 @default.
- W2803660183 cites W2115186092 @default.
- W2803660183 cites W2115898291 @default.
- W2803660183 cites W2117881500 @default.
- W2803660183 cites W2119300420 @default.
- W2803660183 cites W2119301960 @default.
- W2803660183 cites W2120094753 @default.
- W2803660183 cites W2120371872 @default.
- W2803660183 cites W2121563819 @default.
- W2803660183 cites W2122768693 @default.
- W2803660183 cites W2125766343 @default.
- W2803660183 cites W2129514617 @default.
- W2803660183 cites W2132047577 @default.
- W2803660183 cites W2133616955 @default.
- W2803660183 cites W2134764292 @default.
- W2803660183 cites W2138871107 @default.
- W2803660183 cites W2142941142 @default.
- W2803660183 cites W2145396956 @default.
- W2803660183 cites W2146204143 @default.
- W2803660183 cites W2146732755 @default.
- W2803660183 cites W2148218430 @default.
- W2803660183 cites W2151167724 @default.
- W2803660183 cites W2152237318 @default.
- W2803660183 cites W2152974152 @default.
- W2803660183 cites W2157869208 @default.