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- W2803662684 abstract "A catalytic methodology is reported that enables the green, operationally simple and convenient synthesis of corresponding polyfunctionalized piperidine scaffolds via one-pot Knoevenagel- intramolecular [4+2] aza-Diels-Alder imin-based multi-component reaction of between β-ketoesters, aromatic aldehydes and various amines, including some relevant drugs and pharmacologically active derivatives in the presence of biologically active α-amino acid, glutamic acid as a green and biodegradable catalyst. Remarkable E factors, green, readily and inexpensive catalyst, short reaction times, high to excellent yields, mild reaction conditions, high atom-economy and easy isolation procedures are key features of this methodology." @default.
- W2803662684 created "2018-06-01" @default.
- W2803662684 creator A5063712822 @default.
- W2803662684 date "2018-05-24" @default.
- W2803662684 modified "2023-09-26" @default.
- W2803662684 title "Green and Convenient One-Pot Access to Polyfunctionalized Piperidine Scaffolds<i>via</i>Glutamic Acid Catalyzed Knoevenagel- Intramolecular [4+2] aza-Diels-Alder Imin-Based Multi-Component Reaction Under Ambient Temperature" @default.
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- W2803662684 doi "https://doi.org/10.1080/10406638.2018.1472111" @default.
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