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- W2803665654 abstract "Abstract Imiquimod (IMQ) is often used as a topical challenge agent to provoke local skin inflammation. The objective of this study was to develop and refine a rapid, temporary, and reversible human skin inflammation model with IMQ for application in clinical drug development. A randomized, vehicle‐controlled, open‐label, dose‐ranging study was conducted in 16 healthy male subjects. IMQ (5 mg) was applied once daily for 72 hours under occlusion to intact skin ( n = 8) or tape stripped (TS) skin ( n = 8). Although IMQ alone induced limited effects, TS+IMQ treatment showed larger responses in several domains, including erythema and perfusion ( P < 0.0001), mRNA expression of inflammatory markers ( P < 0.01), and inflammatory cell influx compared with vehicle. In conclusion, a rapid, human IMQ skin inflammation challenge model was successfully developed with a clear benefit of TS prior to IMQ application. Future interaction studies will enable proof‐of‐pharmacology of novel compounds targeting the innate immune system ." @default.
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- W2803665654 date "2018-07-03" @default.
- W2803665654 modified "2023-10-17" @default.
- W2803665654 title "Comprehensive, Multimodal Characterization of an Imiquimod‐Induced Human Skin Inflammation Model for Drug Development" @default.
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- W2803665654 doi "https://doi.org/10.1111/cts.12563" @default.
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