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- W2803666057 abstract "Abstract Re‐investigation of the l ‐proline catalyzed double aldol cascade dimerization of succinaldehyde for the synthesis of a key bicyclic enal intermediate, pertinent in the field of stereoselective prostaglandin synthesis, is reported. The yield of this process has been more than doubled, from 14 % to a 29 % isolated yield on a multi‐gram scale (32 % NMR yield), through conducting a detailed study of the reaction solvent, temperature, and concentration, as well as a catalyst screen. The synthetic utility of this enal intermediate has been further demonstrated through the total synthesis of Δ 12 ‐prostaglandin J 3 , a compound with known anti‐leukemic properties." @default.
- W2803666057 created "2018-06-01" @default.
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- W2803666057 date "2018-06-06" @default.
- W2803666057 modified "2023-10-16" @default.
- W2803666057 title "Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of Δ<sup>12</sup>‐Prostaglandin J<sub>3</sub>" @default.
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- W2803666057 doi "https://doi.org/10.1002/chem.201802498" @default.
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