FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803701922> ?p ?o ?g. }

• W2803701922 endingPage "e654" @default.
• W2803701922 startingPage "e654" @default.
• W2803701922 abstract "HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients.To determine the impact of HIV-Tat induction on nociceptive behaviour in female mice conditionally expressing HIV Tat1-86 protein through a doxycycline (DOX)-driven glial fibrillary acidic protein promoter, intraepidermal nerve fibre density and immune cell activation in the dorsal root ganglion (DRG) and spinal cord were assessed by immunohistochemistry. Mice were assessed for mechanical and thermal sensitivity for 9 weeks using von-Frey and Hargreaves tests.Intraepidermal nerve fibre density was significantly reduced after 6 weeks of Tat induction, similar to sensory neuropathy seen in clinical HIV infection. Tat induction through DOX caused a significant reduction in paw withdrawal thresholds in a time-dependent manner starting the 4th week after Tat induction. No changes in paw withdrawal latencies were seen in Tat(-) control mice lacking the tat transgene. Although reductions in paw withdrawal thresholds increased throughout the study, no significant change in spontaneous motor activity was observed. Spinal cord (cervical and lumbar), DRG, and hind paw skin were collected at 8 days and 6 weeks after Tat induction. HIV-Tat mRNA expression was significantly increased in lumbar DRG and skin samples 8 days after DOX treatment. Tat induced a significant increase in the number of Iba-1 positive cells at 6 weeks, but not after 8 days, of exposure. No differences in glial fibrillary acidic protein immunoreactivity were observed.These results suggest that Tat protein contributes to painful HIV-related sensory neuropathy during the initial stages of the pathogenesis." @default.
• W2803701922 created "2018-06-01" @default.
• W2803701922 creator A5014443035 @default.
• W2803701922 creator A5015383366 @default.
• W2803701922 creator A5036036065 @default.
• W2803701922 creator A5046575141 @default.
• W2803701922 creator A5061374409 @default.
• W2803701922 creator A5074477651 @default.
• W2803701922 creator A5076458805 @default.
• W2803701922 creator A5079604087 @default.
• W2803701922 creator A5084871131 @default.
• W2803701922 creator A5086126417 @default.
• W2803701922 date "2018-05-01" @default.
• W2803701922 modified "2023-09-26" @default.
• W2803701922 title "Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy" @default.
• W2803701922 cites W1508155557 @default.
• W2803701922 cites W1576913287 @default.
• W2803701922 cites W1581076164 @default.
• W2803701922 cites W1581091695 @default.
• W2803701922 cites W1601556547 @default.
• W2803701922 cites W1823836002 @default.
• W2803701922 cites W1947896897 @default.
• W2803701922 cites W1964746292 @default.
• W2803701922 cites W1971091888 @default.
• W2803701922 cites W1974835419 @default.
• W2803701922 cites W1977677421 @default.
• W2803701922 cites W1978919566 @default.
• W2803701922 cites W1979638441 @default.
• W2803701922 cites W1984144008 @default.
• W2803701922 cites W1984516384 @default.
• W2803701922 cites W1988502367 @default.
• W2803701922 cites W1989815258 @default.
• W2803701922 cites W1996476108 @default.
• W2803701922 cites W1998529637 @default.
• W2803701922 cites W1999544109 @default.
• W2803701922 cites W2000203727 @default.
• W2803701922 cites W2002816700 @default.
• W2803701922 cites W2006525919 @default.
• W2803701922 cites W2007954332 @default.
• W2803701922 cites W2009429694 @default.
• W2803701922 cites W2021710838 @default.
• W2803701922 cites W2023592074 @default.
• W2803701922 cites W2029843028 @default.
• W2803701922 cites W2031298329 @default.
• W2803701922 cites W2033210129 @default.
• W2803701922 cites W2039683993 @default.
• W2803701922 cites W2041039753 @default.
• W2803701922 cites W2042962510 @default.
• W2803701922 cites W2043353511 @default.
• W2803701922 cites W2044484847 @default.
• W2803701922 cites W2044887735 @default.
• W2803701922 cites W2062174971 @default.
• W2803701922 cites W2063162804 @default.
• W2803701922 cites W2063677740 @default.
• W2803701922 cites W2065498173 @default.
• W2803701922 cites W2067476075 @default.
• W2803701922 cites W2067592236 @default.
• W2803701922 cites W2071908346 @default.
• W2803701922 cites W2074240161 @default.
• W2803701922 cites W2074478455 @default.
• W2803701922 cites W2077012020 @default.
• W2803701922 cites W2078748170 @default.
• W2803701922 cites W2081097226 @default.
• W2803701922 cites W2084251620 @default.
• W2803701922 cites W2088571422 @default.
• W2803701922 cites W2089431194 @default.
• W2803701922 cites W2091137164 @default.
• W2803701922 cites W2094137936 @default.
• W2803701922 cites W2102067045 @default.
• W2803701922 cites W2103379771 @default.
• W2803701922 cites W2110244140 @default.
• W2803701922 cites W2118545611 @default.
• W2803701922 cites W2119395157 @default.
• W2803701922 cites W2126787868 @default.
• W2803701922 cites W2134557769 @default.
• W2803701922 cites W2134914347 @default.
• W2803701922 cites W2140130356 @default.
• W2803701922 cites W2140802115 @default.
• W2803701922 cites W2149903896 @default.
• W2803701922 cites W2154473027 @default.
• W2803701922 cites W2164240213 @default.
• W2803701922 cites W2172201406 @default.
• W2803701922 cites W2196308323 @default.
• W2803701922 cites W2225825761 @default.
• W2803701922 cites W2299116123 @default.
• W2803701922 cites W2322798515 @default.
• W2803701922 cites W2323275321 @default.
• W2803701922 cites W2351778937 @default.
• W2803701922 cites W2473135279 @default.
• W2803701922 cites W2520219328 @default.
• W2803701922 cites W25262361 @default.
• W2803701922 cites W2584429733 @default.
• W2803701922 cites W2756614610 @default.
• W2803701922 cites W2782428259 @default.
• W2803701922 cites W280557804 @default.
• W2803701922 doi "https://doi.org/10.1097/pr9.0000000000000654" @default.
• W2803701922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5999412" @default.
• W2803701922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29922746" @default.

• next