FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803702013> ?p ?o ?g. }

• W2803702013 endingPage "3033" @default.
• W2803702013 startingPage "3025" @default.
• W2803702013 abstract "LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway Jing Ke,1,2 Peng Ma,2 Jinpeng Chen,2 Jun Qin,2 Haixin Qian1 1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of General Surgery, The Affiliated Hospital of Nantong University, Nantong, People’s Republic of China Background: In the present study, we aimed to investigate the role of LGR6 in the progression of gastric cancer (GC) and explore the intrinsic molecular mechanisms.Materials and methods: The lentiviral LGR6 shRNA (sh-LGR6) and lentiviral expression vector of LGR6 gene (OE-LGR6) were used to regulate the LGR6 expression. Furthermore, we performed in vitro experiments to observe whether PI3K/AKT/mTOR pathway was affected by LGR6 and assess the role of LGR6 in the proliferation, apoptosis, migration, and invasion of GC cells.Results: Our data showed that phosphorylated AKT and mTOR were downregulated by sh-LGR6 (P<0.05). The expressions of proapoptotic proteins Bax and Caspase-3 were upregulated by sh-LGR6 (P<0.05); the expression of antiapoptotic protein Bcl2 was downregulated by sh-LGR6 (P<0.001). Besides, the functional experiments proved that sh-LGR6 could promote the apoptosis of GC cells and inhibit the proliferation, invasion, and migration of GC cells (P<0.001). Compared with sh-LGR6, OE-LGR6 led to the opposite results.Conclusion: LGR6 is an antiapoptosis protein which controls the progression of GC through PI3K/AKT/mTOR pathway. More in vivo experiments and clinical trials are necessary to confirm the possibility of LGR6 in tumor therapy. Keywords: LGR6, pathway, tumor therapy, gastric cancer" @default.
• W2803702013 created "2018-06-01" @default.
• W2803702013 creator A5035202234 @default.
• W2803702013 creator A5063891979 @default.
• W2803702013 creator A5064099072 @default.
• W2803702013 creator A5079342142 @default.
• W2803702013 creator A5081851067 @default.
• W2803702013 date "2018-05-01" @default.
• W2803702013 modified "2023-10-16" @default.
• W2803702013 title "LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway" @default.
• W2803702013 cites W1615546978 @default.
• W2803702013 cites W1861033863 @default.
• W2803702013 cites W1897016067 @default.
• W2803702013 cites W1989258758 @default.
• W2803702013 cites W2000263590 @default.
• W2803702013 cites W2011217149 @default.
• W2803702013 cites W2011912935 @default.
• W2803702013 cites W2012555541 @default.
• W2803702013 cites W2017303308 @default.
• W2803702013 cites W2020075150 @default.
• W2803702013 cites W2021689495 @default.
• W2803702013 cites W2023525292 @default.
• W2803702013 cites W2066441074 @default.
• W2803702013 cites W2089044039 @default.
• W2803702013 cites W2099434983 @default.
• W2803702013 cites W2099540110 @default.
• W2803702013 cites W2102346197 @default.
• W2803702013 cites W2110651281 @default.
• W2803702013 cites W2133613843 @default.
• W2803702013 cites W2161907879 @default.
• W2803702013 cites W2177024781 @default.
• W2803702013 cites W2272984102 @default.
• W2803702013 cites W2337389805 @default.
• W2803702013 cites W2352962634 @default.
• W2803702013 cites W2435728889 @default.
• W2803702013 cites W2460311891 @default.
• W2803702013 cites W2565163655 @default.
• W2803702013 cites W2590475897 @default.
• W2803702013 cites W2594122437 @default.
• W2803702013 cites W2606203776 @default.
• W2803702013 cites W2741336325 @default.
• W2803702013 doi "https://doi.org/10.2147/ott.s149303" @default.
• W2803702013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5973468" @default.
• W2803702013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29872314" @default.
• W2803702013 hasPublicationYear "2018" @default.
• W2803702013 type Work @default.
• W2803702013 sameAs 2803702013 @default.
• W2803702013 citedByCount "21" @default.
• W2803702013 countsByYear W28037020132018 @default.
• W2803702013 countsByYear W28037020132019 @default.
• W2803702013 countsByYear W28037020132020 @default.
• W2803702013 countsByYear W28037020132021 @default.
• W2803702013 countsByYear W28037020132022 @default.
• W2803702013 countsByYear W28037020132023 @default.
• W2803702013 crossrefType "journal-article" @default.
• W2803702013 hasAuthorship W2803702013A5035202234 @default.
• W2803702013 hasAuthorship W2803702013A5063891979 @default.
• W2803702013 hasAuthorship W2803702013A5064099072 @default.
• W2803702013 hasAuthorship W2803702013A5079342142 @default.
• W2803702013 hasAuthorship W2803702013A5081851067 @default.
• W2803702013 hasBestOaLocation W28037020131 @default.
• W2803702013 hasConcept C104317684 @default.
• W2803702013 hasConcept C121608353 @default.
• W2803702013 hasConcept C126322002 @default.
• W2803702013 hasConcept C127561419 @default.
• W2803702013 hasConcept C173396325 @default.
• W2803702013 hasConcept C190232843 @default.
• W2803702013 hasConcept C190283241 @default.
• W2803702013 hasConcept C502942594 @default.
• W2803702013 hasConcept C54355233 @default.
• W2803702013 hasConcept C71924100 @default.
• W2803702013 hasConcept C75217442 @default.
• W2803702013 hasConcept C86554907 @default.
• W2803702013 hasConcept C86803240 @default.
• W2803702013 hasConceptScore W2803702013C104317684 @default.
• W2803702013 hasConceptScore W2803702013C121608353 @default.
• W2803702013 hasConceptScore W2803702013C126322002 @default.
• W2803702013 hasConceptScore W2803702013C127561419 @default.
• W2803702013 hasConceptScore W2803702013C173396325 @default.
• W2803702013 hasConceptScore W2803702013C190232843 @default.
• W2803702013 hasConceptScore W2803702013C190283241 @default.
• W2803702013 hasConceptScore W2803702013C502942594 @default.
• W2803702013 hasConceptScore W2803702013C54355233 @default.
• W2803702013 hasConceptScore W2803702013C71924100 @default.
• W2803702013 hasConceptScore W2803702013C75217442 @default.
• W2803702013 hasConceptScore W2803702013C86554907 @default.
• W2803702013 hasConceptScore W2803702013C86803240 @default.
• W2803702013 hasLocation W28037020131 @default.
• W2803702013 hasLocation W28037020132 @default.
• W2803702013 hasLocation W28037020133 @default.
• W2803702013 hasLocation W28037020134 @default.
• W2803702013 hasOpenAccess W2803702013 @default.
• W2803702013 hasPrimaryLocation W28037020131 @default.
• W2803702013 hasRelatedWork W1988747615 @default.
• W2803702013 hasRelatedWork W2278983970 @default.
• W2803702013 hasRelatedWork W2362061149 @default.
• W2803702013 hasRelatedWork W2603762427 @default.
• W2803702013 hasRelatedWork W2912656088 @default.

• next