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• W2803709302 abstract "Corrigendum17 April 2001free access TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role controlling the onset of differentiation M. Zannini M. Zannini Search for more papers by this author V. Avantaggiato V. Avantaggiato Search for more papers by this author E. Biffali E. Biffali Search for more papers by this author M.I. Arnone M.I. Arnone Search for more papers by this author K. Sato K. Sato Search for more papers by this author M. Pischetola M. Pischetola Search for more papers by this author B.A. Taylor B.A. Taylor Search for more papers by this author S.J. Phillips S.J. Phillips Search for more papers by this author A. Simeone A. Simeone Search for more papers by this author R. Di Lauro R. Di Lauro Search for more papers by this author M. Zannini M. Zannini Search for more papers by this author V. Avantaggiato V. Avantaggiato Search for more papers by this author E. Biffali E. Biffali Search for more papers by this author M.I. Arnone M.I. Arnone Search for more papers by this author K. Sato K. Sato Search for more papers by this author M. Pischetola M. Pischetola Search for more papers by this author B.A. Taylor B.A. Taylor Search for more papers by this author S.J. Phillips S.J. Phillips Search for more papers by this author A. Simeone A. Simeone Search for more papers by this author R. Di Lauro R. Di Lauro Search for more papers by this author Author Information M. Zannini, V. Avantaggiato, E. Biffali, M.I. Arnone, K. Sato, M. Pischetola, B.A. Taylor, S.J. Phillips, A. Simeone and R. Di Lauro The EMBO Journal (2001)20:2108-2108https://doi.org/10.1093/emboj/20.8.2108 This article corrects the following: TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation01 June 1997 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info In this paper the cloning of a cDNA encoding a forkhead containing transcription factor, denominated TTF-2, was reported. In Figure 8 we showed the expression of TTF-2 in the developing thyroid at embryonic days (E) 13.5 and 15, demonstrating a down-regulation of TTF-2 expression at E15 (panel D). Figure 1.(D) In situ hybridization on a sagittal section of mouse embryo at E15.5 using a TTF-2 specific probe. TTF-2 mRNA is clearly expressed in thyroid cells at this stage. Download figure Download PowerPoint In repeating these experiments with a novel TTF-2 probe that gives a stronger signal and that includes the sequence used as a probe in the original manuscript, we have been unable to confirm such down-regulation. The figure below, that should substitute panel D in Figure 8 of the original manuscript, shows the hybridization signal that we now routinely obtain on sections of E15 thyroid with the new TTF-2 probe. The presence of TTF-2 in E15 thyroids has also been confirmed with a newly developed anti-TTF-2 antibody (data not shown). Thus, TTF-2 expression in thyroid development shows no discontinuity. As a consequence, the hypothesis presented in the original manuscript proposing that the onset of differentiation correlated with disappearance of TTF-2 is no longer supported. However, all other data presented in the manuscript have been confirmed, including the repression activity of TTF-2 (Perrone et al., 2000). Finally, the presence of TTF-2 in the developing thyroid, even if not discontinuous, has since been demonstrated to be of relevance in mice (De Felice et al., 1998) and humans (Clifton-Bligh et al., 1998). Rosanna Parlato, Antonio Simeone, Mario De Felice and Roberto Di Lauro References Clifton-Bligh RJ, Wentworth JM, Heinz P, Crisp MS, John R, Lazarus JH, Ludgate M and Chatterjee VK (1998) Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanla atresia. Nature Genet, 19, 339–401.CrossrefWeb of Science®Google Scholar De Felice M et al. (1998) A mouse model for hereditary thyroid dysgenesis and cleft palate. Nature Genet, 19, 395–398.CrossrefCASPubMedWeb of Science®Google Scholar Perrone L, Pasca di Magliano M, Zannini M and Di Lauro R (2000) The thyroid transcription factor 2 (TTF-2) is a promoter-specific DNA-binding independent transcriptional repressor. Biochem Biophys Res Commun, 275, 203–208.CrossrefCASPubMedWeb of Science®Google Scholar Next ArticlePrevious Article Read MoreAbout the coverClose modalView large imageVolume 20,Issue 8,April 17, 2001Cover. A confocal micrograph of cultured primary rat neonatal ventriculocytes following induction of hypertrophy after exposure to phenylephrine. Dodge et al. have demonstrated the formation of a signaling complex in heart tissues that includes mAKAP (blue), cAMP-dependent protein kinase A (PKA) and cAMP-specific phosphodiesterase (PDE4D3; green), to maintain a negative feedback loop. Actin (red) displays a characteristic pattern associated with hypertrophy in these cells. Imaging was carried out in a BioRad MRC1024UV/VIS confocal microscope. John D.Scott is a Howard Hughes Medical Institute Associate Investigator and a Senior Scientist at the Vollum Institute in Portland, Oregon. For further details see Dodge et al., pages 1921--1930. Volume 20Issue 817 April 2001In this issue FiguresReferencesRelatedDetailsLoading ..." @default.
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