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• W2803718934 startingPage "117793221875533" @default.
• W2803718934 abstract "Caseous lymphadenitis (CLA) is a disease caused by Corynebacterium pseudotuberculosis bacteria that affects sheep and goats. The absence of a serologic diagnose is a factor that contributes for the disease dissemination, and due to the formation of granuloma, the treatment is very expensive. Therefore, prophylaxis is the approach with best cost-benefit relation; however, it still lacks an effective vaccine. In this sense, this work seeks to apply bioinformatic tools to design an effective vaccine against CLA, using CP40 protein as standard for the design of immunodominant epitopes, from which a total of 6 sequences were obtained, varying from 10 to 16 amino acid residues. The evaluation of different properties of the vaccines showed that the vaccine is a potent and nonallergenic antigen remaining stable in a wide range of temperatures. The initial tertiary structure of the vaccine was then predicted and a model selected. Later, the process of CP40 protein and TLR2 receptor binding was performed, presenting interaction with this receptor, which plays an important role in the activation of the immune response." @default.
• W2803718934 created "2018-06-01" @default.
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• W2803718934 date "2018-01-01" @default.
• W2803718934 modified "2023-09-27" @default.
• W2803718934 title "Immune-Informatic Analysis and Design of Peptide Vaccine From Multi-epitopes Against <i>Corynebacterium pseudotuberculosis</i>" @default.
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• W2803718934 doi "https://doi.org/10.1177/1177932218755337" @default.
• W2803718934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5954444" @default.
• W2803718934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29780242" @default.
• W2803718934 hasPublicationYear "2018" @default.
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