Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803750312> ?p ?o ?g. }
- W2803750312 endingPage "159" @default.
- W2803750312 startingPage "159" @default.
- W2803750312 abstract "The multi-functional cytokine transforming growth factor-β1 (TGF-β1) has growth inhibitory and anti-inflammatory roles during homeostasis and the early stages of cancer. Aberrant TGF-β activation in the late-stages of tumorigenesis, however, promotes development of aggressive growth characteristics and metastatic spread. Given the critical importance of this growth factor in fibrotic and neoplastic disorders, the TGF-β1 network is subject to extensive, multi-level negative controls that impact receptor function, mothers against decapentaplegic homolog 2/3 (SMAD2/3) activation, intracellular signal bifurcation into canonical and non-canonical pathways and target gene promotor engagement. Such negative regulators include phosphatase and tensin homologue (PTEN), protein phosphatase magnesium 1A (PPM1A), Klotho, bone morphogenic protein 7 (BMP7), SMAD7, Sloan-Kettering Institute proto-oncogene/ Ski related novel gene (Ski/SnoN), and bone morphogenetic protein and activin membrane-bound Inhibitor (BAMBI). The progression of certain cancers is accompanied by loss of expression, overexpression, mislocalization, mutation or deletion of several endogenous repressors of the TGF-β1 cascade, further modulating signal duration/intensity and phenotypic reprogramming. This review addresses how their aberrant regulation contributes to cellular plasticity, tumor progression/metastasis and reversal of cell cycle arrest and discusses the unexplored therapeutic value of restoring the expression and/or function of these factors as a novel approach to cancer treatment." @default.
- W2803750312 created "2018-06-01" @default.
- W2803750312 creator A5017848456 @default.
- W2803750312 creator A5036216288 @default.
- W2803750312 creator A5046485745 @default.
- W2803750312 creator A5075702453 @default.
- W2803750312 date "2018-05-25" @default.
- W2803750312 modified "2023-09-30" @default.
- W2803750312 title "Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression" @default.
- W2803750312 cites W1498739650 @default.
- W2803750312 cites W1530364143 @default.
- W2803750312 cites W1533133582 @default.
- W2803750312 cites W1547024856 @default.
- W2803750312 cites W1552236594 @default.
- W2803750312 cites W1553444759 @default.
- W2803750312 cites W1553827116 @default.
- W2803750312 cites W1663371441 @default.
- W2803750312 cites W1666089077 @default.
- W2803750312 cites W1806266807 @default.
- W2803750312 cites W1826675132 @default.
- W2803750312 cites W1828456061 @default.
- W2803750312 cites W1964636114 @default.
- W2803750312 cites W1966857167 @default.
- W2803750312 cites W1968044382 @default.
- W2803750312 cites W1971093570 @default.
- W2803750312 cites W1971597989 @default.
- W2803750312 cites W1972207041 @default.
- W2803750312 cites W1973577899 @default.
- W2803750312 cites W1978501763 @default.
- W2803750312 cites W1978882265 @default.
- W2803750312 cites W1979081816 @default.
- W2803750312 cites W1981406615 @default.
- W2803750312 cites W1982498121 @default.
- W2803750312 cites W1990613923 @default.
- W2803750312 cites W1992468405 @default.
- W2803750312 cites W1995160678 @default.
- W2803750312 cites W1996222881 @default.
- W2803750312 cites W1999175291 @default.
- W2803750312 cites W2001351884 @default.
- W2803750312 cites W2003737968 @default.
- W2803750312 cites W2009358874 @default.
- W2803750312 cites W2009396278 @default.
- W2803750312 cites W2014226478 @default.
- W2803750312 cites W2014409388 @default.
- W2803750312 cites W2014483534 @default.
- W2803750312 cites W2014988372 @default.
- W2803750312 cites W2017739035 @default.
- W2803750312 cites W2018588230 @default.
- W2803750312 cites W2019167816 @default.
- W2803750312 cites W2021755901 @default.
- W2803750312 cites W2022066131 @default.
- W2803750312 cites W2024031250 @default.
- W2803750312 cites W2027130619 @default.
- W2803750312 cites W2028348480 @default.
- W2803750312 cites W2029774571 @default.
- W2803750312 cites W2032304802 @default.
- W2803750312 cites W2034779933 @default.
- W2803750312 cites W2035653659 @default.
- W2803750312 cites W2037692396 @default.
- W2803750312 cites W2038654036 @default.
- W2803750312 cites W2039907359 @default.
- W2803750312 cites W2043409210 @default.
- W2803750312 cites W2047913098 @default.
- W2803750312 cites W2051190668 @default.
- W2803750312 cites W2053006673 @default.
- W2803750312 cites W2054655694 @default.
- W2803750312 cites W2062929087 @default.
- W2803750312 cites W2063391460 @default.
- W2803750312 cites W2064953827 @default.
- W2803750312 cites W2072601177 @default.
- W2803750312 cites W2072645006 @default.
- W2803750312 cites W2072869809 @default.
- W2803750312 cites W2075938087 @default.
- W2803750312 cites W2077810230 @default.
- W2803750312 cites W2078974072 @default.
- W2803750312 cites W2081476887 @default.
- W2803750312 cites W2083276959 @default.
- W2803750312 cites W2087544898 @default.
- W2803750312 cites W2094579915 @default.
- W2803750312 cites W2099361912 @default.
- W2803750312 cites W2100842035 @default.
- W2803750312 cites W2103031848 @default.
- W2803750312 cites W2105712178 @default.
- W2803750312 cites W2114360920 @default.
- W2803750312 cites W2118207122 @default.
- W2803750312 cites W2120299678 @default.
- W2803750312 cites W2124350477 @default.
- W2803750312 cites W2128077493 @default.
- W2803750312 cites W2128275386 @default.
- W2803750312 cites W2132961875 @default.
- W2803750312 cites W2136666186 @default.
- W2803750312 cites W2137720344 @default.
- W2803750312 cites W2138103260 @default.
- W2803750312 cites W2139438301 @default.
- W2803750312 cites W2150073419 @default.
- W2803750312 cites W2150355840 @default.
- W2803750312 cites W2151258296 @default.
- W2803750312 cites W2151260549 @default.