Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803755422> ?p ?o ?g. }
- W2803755422 endingPage "54" @default.
- W2803755422 startingPage "46" @default.
- W2803755422 abstract "Alternative splicing is a key process required for the regulation of gene expression in normal development and physiology. It is regulated by splice factors whose activities are in turn regulated by splice factor kinases and phosphatases. The CDC-like protein kinases are a widespread family of splice factor kinases involved in normal physiology and in several diseases including cancer. In humans they include the CLK1, CLK2, CLK3 and CLK4 genes. The expression of CLK1 is regulated through alternative splicing producing both full-length catalytically active and truncated catalytically inactive isoforms, CLKT1 (arising from exon 4 skipping) and CLKT2 (arising from intron 4 retention). We examined CLK1 alternative splicing in a range of cancer cell lines, and report widespread and highly variable rates of exon 4 skipping and intron 4 retention. We also examined the effect of severe environmental stress including heat shock, osmotic shock, and exposure to the alkaloid drug harmine on CLK1 alternative splicing in DU145 prostate cancer cells. All treatments rapidly reduced exon 4 skipping and intron 4 retention, shifting the balance towards full-length CLK1 expression. We also found that the inhibition of CLK1 with the benzothiazole TG003 reduced exon 4 skipping and intron 4 retention suggesting an autoregulatory mechanism. CLK1 inhibition with TG003 also resulted in modified alternative splicing of five cancer-associated genes." @default.
- W2803755422 created "2018-06-01" @default.
- W2803755422 creator A5040831929 @default.
- W2803755422 creator A5054253910 @default.
- W2803755422 creator A5062924582 @default.
- W2803755422 creator A5067277543 @default.
- W2803755422 creator A5086883712 @default.
- W2803755422 creator A5087181243 @default.
- W2803755422 date "2018-09-01" @default.
- W2803755422 modified "2023-10-13" @default.
- W2803755422 title "Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention" @default.
- W2803755422 cites W1462687379 @default.
- W2803755422 cites W1562141381 @default.
- W2803755422 cites W1712461720 @default.
- W2803755422 cites W1755736350 @default.
- W2803755422 cites W1812729869 @default.
- W2803755422 cites W1965733051 @default.
- W2803755422 cites W1970108031 @default.
- W2803755422 cites W2002137646 @default.
- W2803755422 cites W2004811444 @default.
- W2803755422 cites W2004995604 @default.
- W2803755422 cites W2008962735 @default.
- W2803755422 cites W2010236131 @default.
- W2803755422 cites W2010336934 @default.
- W2803755422 cites W2012098861 @default.
- W2803755422 cites W2029867817 @default.
- W2803755422 cites W2035048099 @default.
- W2803755422 cites W2056401015 @default.
- W2803755422 cites W2063176993 @default.
- W2803755422 cites W2068968408 @default.
- W2803755422 cites W2071948503 @default.
- W2803755422 cites W2074410038 @default.
- W2803755422 cites W2081936386 @default.
- W2803755422 cites W2090453355 @default.
- W2803755422 cites W2095473486 @default.
- W2803755422 cites W2096674266 @default.
- W2803755422 cites W2107977824 @default.
- W2803755422 cites W2114417863 @default.
- W2803755422 cites W2114858580 @default.
- W2803755422 cites W2119963935 @default.
- W2803755422 cites W2122358139 @default.
- W2803755422 cites W2124301111 @default.
- W2803755422 cites W2129682060 @default.
- W2803755422 cites W2130048636 @default.
- W2803755422 cites W2133528590 @default.
- W2803755422 cites W2144154285 @default.
- W2803755422 cites W2153451653 @default.
- W2803755422 cites W2157344394 @default.
- W2803755422 cites W2158982822 @default.
- W2803755422 cites W2165317622 @default.
- W2803755422 cites W2166468632 @default.
- W2803755422 cites W2171929664 @default.
- W2803755422 cites W2188998000 @default.
- W2803755422 cites W2307792848 @default.
- W2803755422 cites W2333316766 @default.
- W2803755422 cites W2342653402 @default.
- W2803755422 cites W2436651704 @default.
- W2803755422 cites W2553545715 @default.
- W2803755422 cites W2564926110 @default.
- W2803755422 cites W2578310144 @default.
- W2803755422 cites W2588002753 @default.
- W2803755422 cites W2616915450 @default.
- W2803755422 cites W2619849647 @default.
- W2803755422 cites W2736127827 @default.
- W2803755422 cites W2761124854 @default.
- W2803755422 cites W2763791174 @default.
- W2803755422 cites W2769207336 @default.
- W2803755422 cites W2799386757 @default.
- W2803755422 doi "https://doi.org/10.1016/j.gene.2018.05.095" @default.
- W2803755422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29802995" @default.
- W2803755422 hasPublicationYear "2018" @default.
- W2803755422 type Work @default.
- W2803755422 sameAs 2803755422 @default.
- W2803755422 citedByCount "25" @default.
- W2803755422 countsByYear W28037554222019 @default.
- W2803755422 countsByYear W28037554222020 @default.
- W2803755422 countsByYear W28037554222021 @default.
- W2803755422 countsByYear W28037554222022 @default.
- W2803755422 countsByYear W28037554222023 @default.
- W2803755422 crossrefType "journal-article" @default.
- W2803755422 hasAuthorship W2803755422A5040831929 @default.
- W2803755422 hasAuthorship W2803755422A5054253910 @default.
- W2803755422 hasAuthorship W2803755422A5062924582 @default.
- W2803755422 hasAuthorship W2803755422A5067277543 @default.
- W2803755422 hasAuthorship W2803755422A5086883712 @default.
- W2803755422 hasAuthorship W2803755422A5087181243 @default.
- W2803755422 hasBestOaLocation W28037554222 @default.
- W2803755422 hasConcept C104317684 @default.
- W2803755422 hasConcept C10447831 @default.
- W2803755422 hasConcept C194583182 @default.
- W2803755422 hasConcept C36823959 @default.
- W2803755422 hasConcept C54355233 @default.
- W2803755422 hasConcept C54458228 @default.
- W2803755422 hasConcept C67705224 @default.
- W2803755422 hasConcept C73758832 @default.
- W2803755422 hasConcept C86803240 @default.
- W2803755422 hasConcept C94671646 @default.
- W2803755422 hasConceptScore W2803755422C104317684 @default.