FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803757688> ?p ?o ?g. }

• W2803757688 abstract "Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by biological and clinical heterogeneity. The interleukin (IL)-1 superfamily is a group of innate cytokines that contribute to pathogenesis in many autoimmune diseases. IL-1β and IL-18 are two members that have been shown to play a role in murine lupus-like models, but their role in human SLE remains poorly understood. Here, IL-1β and IL-18 were quantified by enzyme-linked immunosorbent assay in the serum of healthy controls (HCs) and SLE patients from a prospectively followed cohort. Disease activity and organ damage were assessed using SLE disease activity index 2000 (SLEDAI-2K) and SLE damage index scores (SDI), respectively. 184 SLE patients (mean age 44.9 years, 91% female, 56% double-stranded deoxyribonucleic acid positive) were compared to 52 HC. SLE patients had median [IQR] SLEDAI-2K of 4 [2,6], and SDI of 1 [0-2]. Serum IL-18 levels were statistically significantly higher in SLE patients compared to HCs. Univariable linear regression analyses showed that patients with active renal disease or irreversible organ damage had statistically significantly elevated serum IL-18 levels. The association between serum IL-18 and active renal disease was confirmed in multivariable analysis after adjusting for ethnicity and organ damage. High baseline serum IL-18 levels were associated with organ damage at the subsequent visit. Serum IL-1β levels were not significantly elevated in SLE patients when compared to HCs and had no association with overall or organ-specific disease activity or organ damage in cross-sectional and longitudinal analyses. Our data suggest that serum IL-18 and IL-1β have different clinical implications in SLE, with IL-18 being potentially associated with active renal disease." @default.
• W2803757688 created "2018-06-01" @default.
• W2803757688 creator A5002450796 @default.
• W2803757688 creator A5036855659 @default.
• W2803757688 creator A5043055068 @default.
• W2803757688 creator A5048715081 @default.
• W2803757688 creator A5054786088 @default.
• W2803757688 creator A5055556227 @default.
• W2803757688 creator A5059516509 @default.
• W2803757688 creator A5079096658 @default.
• W2803757688 creator A5087760694 @default.
• W2803757688 creator A5090537154 @default.
• W2803757688 date "2018-06-07" @default.
• W2803757688 modified "2023-10-13" @default.
• W2803757688 title "Analysis of Serum Interleukin (IL)-1β and IL-18 in Systemic Lupus Erythematosus" @default.
• W2803757688 cites W1560359916 @default.
• W2803757688 cites W1647469220 @default.
• W2803757688 cites W1885912605 @default.
• W2803757688 cites W1896868877 @default.
• W2803757688 cites W1932831942 @default.
• W2803757688 cites W1960747349 @default.
• W2803757688 cites W1966939072 @default.
• W2803757688 cites W1968035878 @default.
• W2803757688 cites W1974317358 @default.
• W2803757688 cites W1983493239 @default.
• W2803757688 cites W1993026721 @default.
• W2803757688 cites W2002237224 @default.
• W2803757688 cites W2007053134 @default.
• W2803757688 cites W2018760896 @default.
• W2803757688 cites W2019356477 @default.
• W2803757688 cites W2020000056 @default.
• W2803757688 cites W2038767732 @default.
• W2803757688 cites W2059378930 @default.
• W2803757688 cites W2064856766 @default.
• W2803757688 cites W2070527591 @default.
• W2803757688 cites W2080882856 @default.
• W2803757688 cites W2090627427 @default.
• W2803757688 cites W2093676555 @default.
• W2803757688 cites W2097191004 @default.
• W2803757688 cites W2108905161 @default.
• W2803757688 cites W2111940985 @default.
• W2803757688 cites W2114709756 @default.
• W2803757688 cites W2131457901 @default.
• W2803757688 cites W2133589818 @default.
• W2803757688 cites W2136149088 @default.
• W2803757688 cites W2150535059 @default.
• W2803757688 cites W2155661533 @default.
• W2803757688 cites W2159571049 @default.
• W2803757688 cites W2159860161 @default.
• W2803757688 cites W2162532089 @default.
• W2803757688 cites W2177646845 @default.
• W2803757688 cites W2188988854 @default.
• W2803757688 cites W2199189793 @default.
• W2803757688 cites W2211480306 @default.
• W2803757688 cites W2212304762 @default.
• W2803757688 cites W2235593616 @default.
• W2803757688 cites W2296003278 @default.
• W2803757688 cites W2321809676 @default.
• W2803757688 cites W2402298256 @default.
• W2803757688 cites W2404993483 @default.
• W2803757688 cites W2417023541 @default.
• W2803757688 cites W2500783422 @default.
• W2803757688 cites W2522112604 @default.
• W2803757688 cites W2528995581 @default.
• W2803757688 cites W2529347414 @default.
• W2803757688 cites W2551404503 @default.
• W2803757688 cites W2597227715 @default.
• W2803757688 cites W2625465155 @default.
• W2803757688 cites W2762718920 @default.
• W2803757688 cites W2767352498 @default.
• W2803757688 cites W2767602096 @default.
• W2803757688 cites W315321297 @default.
• W2803757688 cites W31779890 @default.
• W2803757688 doi "https://doi.org/10.3389/fimmu.2018.01250" @default.
• W2803757688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5999794" @default.
• W2803757688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29930551" @default.
• W2803757688 hasPublicationYear "2018" @default.
• W2803757688 type Work @default.
• W2803757688 sameAs 2803757688 @default.
• W2803757688 citedByCount "76" @default.
• W2803757688 countsByYear W28037576882018 @default.
• W2803757688 countsByYear W28037576882019 @default.
• W2803757688 countsByYear W28037576882020 @default.
• W2803757688 countsByYear W28037576882021 @default.
• W2803757688 countsByYear W28037576882022 @default.
• W2803757688 countsByYear W28037576882023 @default.
• W2803757688 crossrefType "journal-article" @default.
• W2803757688 hasAuthorship W2803757688A5002450796 @default.
• W2803757688 hasAuthorship W2803757688A5036855659 @default.
• W2803757688 hasAuthorship W2803757688A5043055068 @default.
• W2803757688 hasAuthorship W2803757688A5048715081 @default.
• W2803757688 hasAuthorship W2803757688A5054786088 @default.
• W2803757688 hasAuthorship W2803757688A5055556227 @default.
• W2803757688 hasAuthorship W2803757688A5059516509 @default.
• W2803757688 hasAuthorship W2803757688A5079096658 @default.
• W2803757688 hasAuthorship W2803757688A5087760694 @default.
• W2803757688 hasAuthorship W2803757688A5090537154 @default.
• W2803757688 hasBestOaLocation W28037576881 @default.
• W2803757688 hasConcept C126322002 @default.
• W2803757688 hasConcept C159654299 @default.

• next