FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803757730> ?p ?o ?g. }

• W2803757730 endingPage "383" @default.
• W2803757730 startingPage "375" @default.
• W2803757730 abstract "Nitric oxide (NO)-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) have been developed to overcome the gastrointestinal and cardiovascular toxicity of NSAIDs, by chemically associating a NO-releasing moiety with commercial NSAIDs. Since increasing evidence supports that NSAIDs toxicity is related to their topical actions in membrane lipids, this work aims to evaluate the impact of adding a NO-releasing moiety to parent NSAIDs regarding their effect on lipid bilayers. Thus, the interactions of NO-indomethacin and indomethacin (parent drug) with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayers were described herein at pH 3.0 and 7.4. Diverse experimental techniques were combined to characterize the partitioning and location of drugs in DMPC bilayers, and to analyze their effect on the lipid phase transition and the bilayer structure and dynamics. The partitioning of NO-indomethacin into DMPC bilayers was similar to that of charged indomethacin and smaller than that of neutral indomethacin. Both drugs were found to insert the DMPC bilayer and the membrane location of indomethacin was pH-dependent. NO-indomethacin and indomethacin induced a decrease of the main phase transition temperature of DMPC. The effect of these drugs on the bilayer structure and dynamics was dependent on diverse factors, namely drug ionization state, drug:lipid molar ratio, temperature and lipid phase. It is noteworthy that NO-indomethacin induced more pronounced alterations in the biophysical properties of DMPC bilayers than indomethacin, considering equivalent membrane concentrations. Such modifications may have in vivo implications, particularly in the gastric mucosa, where NO-NSAIDs-induced changes in the protective properties of phospholipid layers may contribute to the occurrence of adverse effects." @default.
• W2803757730 created "2018-06-01" @default.
• W2803757730 creator A5011097100 @default.
• W2803757730 creator A5013017184 @default.
• W2803757730 creator A5016723787 @default.
• W2803757730 creator A5053032752 @default.
• W2803757730 creator A5056961988 @default.
• W2803757730 creator A5065533098 @default.
• W2803757730 creator A5070554583 @default.
• W2803757730 date "2018-09-01" @default.
• W2803757730 modified "2023-10-06" @default.
• W2803757730 title "Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?" @default.
• W2803757730 cites W1964833962 @default.
• W2803757730 cites W1969901783 @default.
• W2803757730 cites W1976209618 @default.
• W2803757730 cites W1976570168 @default.
• W2803757730 cites W1980279815 @default.
• W2803757730 cites W1989467672 @default.
• W2803757730 cites W1996230064 @default.
• W2803757730 cites W1998692503 @default.
• W2803757730 cites W1999924165 @default.
• W2803757730 cites W2000959972 @default.
• W2803757730 cites W2003418017 @default.
• W2803757730 cites W2003709444 @default.
• W2803757730 cites W2009475191 @default.
• W2803757730 cites W2013664243 @default.
• W2803757730 cites W2013912675 @default.
• W2803757730 cites W2015713265 @default.
• W2803757730 cites W2019251493 @default.
• W2803757730 cites W2021081864 @default.
• W2803757730 cites W2023036490 @default.
• W2803757730 cites W2027069522 @default.
• W2803757730 cites W2027643417 @default.
• W2803757730 cites W2030847711 @default.
• W2803757730 cites W2034574585 @default.
• W2803757730 cites W2046370344 @default.
• W2803757730 cites W2050277650 @default.
• W2803757730 cites W2054465749 @default.
• W2803757730 cites W2062150631 @default.
• W2803757730 cites W2074889361 @default.
• W2803757730 cites W2075823247 @default.
• W2803757730 cites W2081521523 @default.
• W2803757730 cites W2081932070 @default.
• W2803757730 cites W2088588419 @default.
• W2803757730 cites W2093133987 @default.
• W2803757730 cites W2097740025 @default.
• W2803757730 cites W2103005476 @default.
• W2803757730 cites W2111350165 @default.
• W2803757730 cites W2112877862 @default.
• W2803757730 cites W2113851858 @default.
• W2803757730 cites W2125872855 @default.
• W2803757730 cites W2133991787 @default.
• W2803757730 cites W2136682153 @default.
• W2803757730 cites W2137539691 @default.
• W2803757730 cites W2142509332 @default.
• W2803757730 cites W2145847261 @default.
• W2803757730 cites W2151204014 @default.
• W2803757730 cites W2155674292 @default.
• W2803757730 cites W2156842438 @default.
• W2803757730 cites W2170344807 @default.
• W2803757730 cites W2216938449 @default.
• W2803757730 cites W2315970421 @default.
• W2803757730 cites W2333346662 @default.
• W2803757730 cites W2335028169 @default.
• W2803757730 cites W2532688163 @default.
• W2803757730 cites W2567420691 @default.
• W2803757730 cites W2587983445 @default.
• W2803757730 cites W2611626585 @default.
• W2803757730 cites W318616184 @default.
• W2803757730 doi "https://doi.org/10.1016/j.colsurfb.2018.05.019" @default.
• W2803757730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29803153" @default.
• W2803757730 hasPublicationYear "2018" @default.
• W2803757730 type Work @default.
• W2803757730 sameAs 2803757730 @default.
• W2803757730 citedByCount "12" @default.
• W2803757730 countsByYear W28037577302019 @default.
• W2803757730 countsByYear W28037577302020 @default.
• W2803757730 countsByYear W28037577302021 @default.
• W2803757730 countsByYear W28037577302022 @default.
• W2803757730 crossrefType "journal-article" @default.
• W2803757730 hasAuthorship W2803757730A5011097100 @default.
• W2803757730 hasAuthorship W2803757730A5013017184 @default.
• W2803757730 hasAuthorship W2803757730A5016723787 @default.
• W2803757730 hasAuthorship W2803757730A5053032752 @default.
• W2803757730 hasAuthorship W2803757730A5056961988 @default.
• W2803757730 hasAuthorship W2803757730A5065533098 @default.
• W2803757730 hasAuthorship W2803757730A5070554583 @default.
• W2803757730 hasConcept C12554922 @default.
• W2803757730 hasConcept C185154212 @default.
• W2803757730 hasConcept C185592680 @default.
• W2803757730 hasConcept C192157962 @default.
• W2803757730 hasConcept C202751555 @default.
• W2803757730 hasConcept C2776568683 @default.
• W2803757730 hasConcept C2776980637 @default.
• W2803757730 hasConcept C2778484676 @default.
• W2803757730 hasConcept C2778918659 @default.
• W2803757730 hasConcept C2779296319 @default.
• W2803757730 hasConcept C2780035454 @default.

• next