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• W2803794763 abstract "Six kava analogues of the structural type 3-oxocyclohex-1-en-1-yl benzoates (and corresponding benzamides) were synthesized and evaluated for their affect on periodontal deconstruction in collagen anti-body primed oral gavage model of periodontitis. The compounds were prepared through an acylation or amidation of the enolizable cyclic 1,3-diketone. We have learned that three of the analogues are responsible for the reduction of inflammatory cell counts within soft tissue. These novel kava-like molecules where the lactone is replaced by an α,β-unsaturated ketone show promise in the prevention and treatment of inflammation and alveolar bone loss associated with periodontitis." @default.
• W2803794763 created "2018-06-01" @default.
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• W2803794763 date "2018-09-01" @default.
• W2803794763 modified "2023-09-25" @default.
• W2803794763 title "Kava analogues as agents for treatment of periodontal diseases: Synthesis and initial biological evaluation" @default.
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• W2803794763 doi "https://doi.org/10.1016/j.bmcl.2018.05.026" @default.
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