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- W2803862473 abstract "Signalling from cell-to-cell is fundamental for determining differentiation and patterning. This communication can occur between adjacent and distant cells. Extracellular vesicles (EVs) are membrane-based structures thought to facilitate the long-distance movement of signalling molecules. EVs have recently been found to allow the transport of two major developmental signalling pathways: Hedgehog and Wnt. These signalling molecules undergo crucial post-translational lipid modifications, which anchor them to membranes and impede their free release into the extracellular space. Preparation of these ligands in EVs involves intracellular vesicle sorting in an endocytosis-dependent recycling process before secretion. In the present review, we discuss the most recent advances with regard to EV involvement in developmental signalling at a distance. We focus on the role of the protein complexes involved in EV genesis, and provide a comprehensive perspective of the contribution of these complexes to intracellular vesicle sorting of developmental signals for their extracellular secretion, reception and transduction." @default.
- W2803862473 created "2018-06-01" @default.
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- W2803862473 date "2018-05-15" @default.
- W2803862473 modified "2023-09-26" @default.
- W2803862473 title "From intra- to extracellular vesicles: extracellular vesicles in developmental signalling" @default.
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- W2803862473 doi "https://doi.org/10.1042/ebc20180001" @default.
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