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• W2803871271 abstract "ABSTRACT The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa , Acinetobacter baumannii , and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log 10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, whereas wound infections by K. pneumoniae were less responsive (<1-log 10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections." @default.
• W2803871271 created "2018-06-01" @default.
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• W2803871271 date "2018-05-01" @default.
• W2803871271 modified "2023-09-25" @default.
• W2803871271 title "A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens" @default.
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• W2803871271 doi "https://doi.org/10.1128/aac.02527-17" @default.
• W2803871271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5923121" @default.
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