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• W2803875145 abstract "Biological phase transitions form membrane-less organelles that generate distinct cellular environments. How molecules are partitioned between these compartments and the surrounding cellular space and the functional consequence of this localization is not well understood. Here, we report the localization of mRNA to stress granules (SGs) and processing bodies (PBs) and its effect on translation and degradation during the integrated stress response. Using single mRNA imaging in living human cells, we find that the interactions of mRNAs with SGs and PBs have different dynamics, very few mRNAs directly move between SGs and PBs, and that specific RNA-binding proteins can anchor mRNAs within these compartments. During recovery from stress, we show that mRNAs that were within SGs and PBs are translated and degraded at similar rates as their cytosolic counterparts. Our work provides a framework for using single-molecule measurements to directly investigate the molecular mechanisms of phase-separated compartments within their cellular environment." @default.
• W2803875145 created "2018-06-01" @default.
• W2803875145 creator A5010817393 @default.
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• W2803875145 date "2019-03-01" @default.
• W2803875145 modified "2023-10-14" @default.
• W2803875145 title "Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response" @default.
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• W2803875145 doi "https://doi.org/10.1016/j.molcel.2018.12.006" @default.
• W2803875145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30661979" @default.
• W2803875145 hasPublicationYear "2019" @default.
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