FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803947488> ?p ?o ?g. }

• W2803947488 endingPage "854" @default.
• W2803947488 startingPage "848" @default.
• W2803947488 abstract "In early embryos, microtubules form star-shaped aster structures that can measure up to hundreds of micrometres, and move at high speeds to find the geometrical centre of the cell. This process, known as aster centration, is essential for the fidelity of cell division and development, but how cells succeed in moving these large structures through their crowded and fluctuating cytoplasm remains unclear. Here, we demonstrate that the positional fluctuations of migrating sea urchin sperm asters are small, anisotropic, and associated with the stochasticity of dynein-dependent forces moving the aster. Using in vivo magnetic tweezers to directly measure aster forces inside cells, we derive a linear aster force-velocity relationship and provide evidence for a spring-like active mechanism stabilizing the transverse position of the asters. The large frictional coefficient and spring constant quantitatively account for the amplitude and growth characteristics of athermal positional fluctuations, demonstrating that aster mechanics ensure noise suppression to promote persistent and precise centration. These findings define generic biophysical regimes of active cytoskeletal mechanics underlying the accuracy of cell division and early embryonic development." @default.
• W2803947488 created "2018-06-01" @default.
• W2803947488 creator A5003316260 @default.
• W2803947488 creator A5033215238 @default.
• W2803947488 creator A5043030910 @default.
• W2803947488 creator A5083021758 @default.
• W2803947488 date "2018-05-28" @default.
• W2803947488 modified "2023-10-17" @default.
• W2803947488 title "Physical forces determining the persistency and centring precision of microtubule asters" @default.
• W2803947488 cites W1497716111 @default.
• W2803947488 cites W1555728672 @default.
• W2803947488 cites W1558995344 @default.
• W2803947488 cites W1955495375 @default.
• W2803947488 cites W1964726582 @default.
• W2803947488 cites W1972174678 @default.
• W2803947488 cites W1975928024 @default.
• W2803947488 cites W1996923295 @default.
• W2803947488 cites W2007368235 @default.
• W2803947488 cites W2007496445 @default.
• W2803947488 cites W2031818488 @default.
• W2803947488 cites W2034728705 @default.
• W2803947488 cites W2044987021 @default.
• W2803947488 cites W2046963960 @default.
• W2803947488 cites W2048141009 @default.
• W2803947488 cites W2048718074 @default.
• W2803947488 cites W2079137734 @default.
• W2803947488 cites W2103949858 @default.
• W2803947488 cites W2152251468 @default.
• W2803947488 cites W2152969835 @default.
• W2803947488 cites W2157073047 @default.
• W2803947488 cites W2162802670 @default.
• W2803947488 cites W2164585663 @default.
• W2803947488 cites W2171939937 @default.
• W2803947488 cites W2286403714 @default.
• W2803947488 cites W2330649502 @default.
• W2803947488 cites W2399690657 @default.
• W2803947488 cites W2399785989 @default.
• W2803947488 cites W2567413041 @default.
• W2803947488 cites W2790854282 @default.
• W2803947488 cites W2794387143 @default.
• W2803947488 cites W2953106150 @default.
• W2803947488 cites W2963822633 @default.
• W2803947488 cites W4246090814 @default.
• W2803947488 doi "https://doi.org/10.1038/s41567-018-0154-4" @default.
• W2803947488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6071857" @default.
• W2803947488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30079097" @default.
• W2803947488 hasPublicationYear "2018" @default.
• W2803947488 type Work @default.
• W2803947488 sameAs 2803947488 @default.
• W2803947488 citedByCount "43" @default.
• W2803947488 countsByYear W28039474882018 @default.
• W2803947488 countsByYear W28039474882019 @default.
• W2803947488 countsByYear W28039474882020 @default.
• W2803947488 countsByYear W28039474882021 @default.
• W2803947488 countsByYear W28039474882022 @default.
• W2803947488 countsByYear W28039474882023 @default.
• W2803947488 crossrefType "journal-article" @default.
• W2803947488 hasAuthorship W2803947488A5003316260 @default.
• W2803947488 hasAuthorship W2803947488A5033215238 @default.
• W2803947488 hasAuthorship W2803947488A5043030910 @default.
• W2803947488 hasAuthorship W2803947488A5083021758 @default.
• W2803947488 hasBestOaLocation W28039474882 @default.
• W2803947488 hasConcept C106987784 @default.
• W2803947488 hasConcept C121332964 @default.
• W2803947488 hasConcept C1276947 @default.
• W2803947488 hasConcept C13772937 @default.
• W2803947488 hasConcept C19269812 @default.
• W2803947488 hasConcept C20418707 @default.
• W2803947488 hasConcept C2780009758 @default.
• W2803947488 hasConcept C41008148 @default.
• W2803947488 hasConcept C77088390 @default.
• W2803947488 hasConcept C86803240 @default.
• W2803947488 hasConcept C95444343 @default.
• W2803947488 hasConceptScore W2803947488C106987784 @default.
• W2803947488 hasConceptScore W2803947488C121332964 @default.
• W2803947488 hasConceptScore W2803947488C1276947 @default.
• W2803947488 hasConceptScore W2803947488C13772937 @default.
• W2803947488 hasConceptScore W2803947488C19269812 @default.
• W2803947488 hasConceptScore W2803947488C20418707 @default.
• W2803947488 hasConceptScore W2803947488C2780009758 @default.
• W2803947488 hasConceptScore W2803947488C41008148 @default.
• W2803947488 hasConceptScore W2803947488C77088390 @default.
• W2803947488 hasConceptScore W2803947488C86803240 @default.
• W2803947488 hasConceptScore W2803947488C95444343 @default.
• W2803947488 hasIssue "8" @default.
• W2803947488 hasLocation W28039474881 @default.
• W2803947488 hasLocation W280394748810 @default.
• W2803947488 hasLocation W28039474882 @default.
• W2803947488 hasLocation W28039474883 @default.
• W2803947488 hasLocation W28039474884 @default.
• W2803947488 hasLocation W28039474885 @default.
• W2803947488 hasLocation W28039474886 @default.
• W2803947488 hasLocation W28039474887 @default.
• W2803947488 hasLocation W28039474888 @default.
• W2803947488 hasLocation W28039474889 @default.
• W2803947488 hasOpenAccess W2803947488 @default.
• W2803947488 hasPrimaryLocation W28039474881 @default.
• W2803947488 hasRelatedWork W1974717326 @default.

• next