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• W2803963578 startingPage "185" @default.
• W2803963578 abstract "Various radioactive nanomaterials (radionanomaterials) have been successfully utilized as radionanomedicines, particularly in the field of nuclear imaging and radiation therapy. Surface modification is one of the most critical steps during the fabrication of radionanomedicines. Proper surface modification can bring multiple benefits to radioisotopes-loaded nanomaterials, which include, but not limited to, material disparity/stability improvement, in vivo pharmacokinetics optimization, adjustment of interactions with biomolecules, incorporation of diagnostic or tissue targeting moieties, addition of new material property (e.g. stimuli responsiveness), among many others. In this chapter, we tried to give a brief illustration on how various surface modification strategies can be accomplished for specific nanomaterials, and provide comments on the advantages and limitations of each strategy. By the most straightforward categorization, the surface modification can be achieved via either chemical reactions (covalent coupling) or physical interactions (usually forming noncovalent binding). Each surface modification method can work synergistically with each other to generate theranostic radionanomaterials with more attractive characteristics. In the end, different previous representative research reports were given as examples to confirm how these strategies could be used in surface modification of nanomaterials from different categories." @default.
• W2803963578 created "2018-06-01" @default.
• W2803963578 creator A5027703304 @default.
• W2803963578 creator A5078455821 @default.
• W2803963578 date "2018-01-01" @default.
• W2803963578 modified "2023-09-23" @default.
• W2803963578 title "Surface Modification of Radionanomedicine" @default.
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