FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804013458> ?p ?o ?g. }

• W2804013458 endingPage "12" @default.
• W2804013458 startingPage "1" @default.
• W2804013458 abstract "Airway epithelial cells secrete diverse inflammatory mediators in response to various stimuli. Thus, early regulation of immune responses in the airway epithelium is likely critical for the control of chronic inflammatory diseases. The purpose of the present study was to evaluate the effects of 18 β -glycyrrhetinic acid (GA) on inflammatory responses generated in response to a fungal protease allergen that induces epithelial damage. To understand the underlying mechanisms, we also investigated the inhibitory effects of GA on the production of mitochondrial reactive oxygen species (ROS) in the human bronchial epithelial cell line BEAS2B. In this study, GA treatment reduced cytokine production and the human neutrophil cell line HL60 migration through decreased mitochondrial ROS production. In addition, GA significantly reduced inflammatory cell infiltration and cytokine levels in the bronchoalveolar lavage (BAL) fluid of fungal allergen-administered mice. Inhibitory effects of GA are dependent on the mitochondrial ROS/MAPK axis. Moreover, the effect of GA on the regulation of mitochondrial ROS depends on the expression of uncoupling protein-2 (UCP-2). Taken together, GA might represent a potential therapeutic agent for blocking inflammatory responses in airways." @default.
• W2804013458 created "2018-06-01" @default.
• W2804013458 creator A5052838486 @default.
• W2804013458 creator A5063086849 @default.
• W2804013458 creator A5064116218 @default.
• W2804013458 date "2018-01-01" @default.
• W2804013458 modified "2023-10-09" @default.
• W2804013458 title "Effects of 18<i>β</i>-Glycyrrhetinic Acid on Fungal Protease-Induced Airway Inflammatory Responses" @default.
• W2804013458 cites W1674844815 @default.
• W2804013458 cites W1964616617 @default.
• W2804013458 cites W1976599392 @default.
• W2804013458 cites W1985538633 @default.
• W2804013458 cites W1986661099 @default.
• W2804013458 cites W1987652249 @default.
• W2804013458 cites W1992678387 @default.
• W2804013458 cites W2002375125 @default.
• W2804013458 cites W2005574929 @default.
• W2804013458 cites W2011124873 @default.
• W2804013458 cites W2020153915 @default.
• W2804013458 cites W2033448006 @default.
• W2804013458 cites W2036145275 @default.
• W2804013458 cites W2038581981 @default.
• W2804013458 cites W2039472410 @default.
• W2804013458 cites W2042183116 @default.
• W2804013458 cites W2051930121 @default.
• W2804013458 cites W2052567898 @default.
• W2804013458 cites W2056294485 @default.
• W2804013458 cites W2078583104 @default.
• W2804013458 cites W2084735271 @default.
• W2804013458 cites W2092790181 @default.
• W2804013458 cites W2105450045 @default.
• W2804013458 cites W2108105410 @default.
• W2804013458 cites W2108218187 @default.
• W2804013458 cites W2109843249 @default.
• W2804013458 cites W2113432742 @default.
• W2804013458 cites W2113651620 @default.
• W2804013458 cites W2147657681 @default.
• W2804013458 cites W2153091201 @default.
• W2804013458 cites W2154719091 @default.
• W2804013458 cites W2155208388 @default.
• W2804013458 cites W2236876228 @default.
• W2804013458 cites W2411186352 @default.
• W2804013458 cites W2568165160 @default.
• W2804013458 cites W4292820908 @default.
• W2804013458 cites W54064970 @default.
• W2804013458 doi "https://doi.org/10.1155/2018/6461032" @default.
• W2804013458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5976916" @default.
• W2804013458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29861658" @default.
• W2804013458 hasPublicationYear "2018" @default.
• W2804013458 type Work @default.
• W2804013458 sameAs 2804013458 @default.
• W2804013458 citedByCount "9" @default.
• W2804013458 countsByYear W28040134582020 @default.
• W2804013458 countsByYear W28040134582021 @default.
• W2804013458 countsByYear W28040134582022 @default.
• W2804013458 countsByYear W28040134582023 @default.
• W2804013458 crossrefType "journal-article" @default.
• W2804013458 hasAuthorship W2804013458A5052838486 @default.
• W2804013458 hasAuthorship W2804013458A5063086849 @default.
• W2804013458 hasAuthorship W2804013458A5064116218 @default.
• W2804013458 hasBestOaLocation W28040134581 @default.
• W2804013458 hasConcept C126322002 @default.
• W2804013458 hasConcept C164027704 @default.
• W2804013458 hasConcept C203014093 @default.
• W2804013458 hasConcept C2776151105 @default.
• W2804013458 hasConcept C2776914184 @default.
• W2804013458 hasConcept C2777714996 @default.
• W2804013458 hasConcept C2777961210 @default.
• W2804013458 hasConcept C2778175917 @default.
• W2804013458 hasConcept C2778690821 @default.
• W2804013458 hasConcept C48349386 @default.
• W2804013458 hasConcept C49039625 @default.
• W2804013458 hasConcept C529295009 @default.
• W2804013458 hasConcept C54355233 @default.
• W2804013458 hasConcept C55493867 @default.
• W2804013458 hasConcept C71924100 @default.
• W2804013458 hasConcept C86803240 @default.
• W2804013458 hasConcept C87568996 @default.
• W2804013458 hasConcept C8891405 @default.
• W2804013458 hasConcept C95444343 @default.
• W2804013458 hasConceptScore W2804013458C126322002 @default.
• W2804013458 hasConceptScore W2804013458C164027704 @default.
• W2804013458 hasConceptScore W2804013458C203014093 @default.
• W2804013458 hasConceptScore W2804013458C2776151105 @default.
• W2804013458 hasConceptScore W2804013458C2776914184 @default.
• W2804013458 hasConceptScore W2804013458C2777714996 @default.
• W2804013458 hasConceptScore W2804013458C2777961210 @default.
• W2804013458 hasConceptScore W2804013458C2778175917 @default.
• W2804013458 hasConceptScore W2804013458C2778690821 @default.
• W2804013458 hasConceptScore W2804013458C48349386 @default.
• W2804013458 hasConceptScore W2804013458C49039625 @default.
• W2804013458 hasConceptScore W2804013458C529295009 @default.
• W2804013458 hasConceptScore W2804013458C54355233 @default.
• W2804013458 hasConceptScore W2804013458C55493867 @default.
• W2804013458 hasConceptScore W2804013458C71924100 @default.
• W2804013458 hasConceptScore W2804013458C86803240 @default.
• W2804013458 hasConceptScore W2804013458C87568996 @default.
• W2804013458 hasConceptScore W2804013458C8891405 @default.

• next