FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804032488> ?p ?o ?g. }

• W2804032488 abstract "Abstract Background Sri Lanka experienced the largest ever dengue outbreak in year 2017, which coincided with the shift of the predominant circulating dengue virus (DENV) 1 to DENV2 after 9 years. As it was felt that more patients appeared to develop complications and severe dengue, we compared clinical features of patients with acute dengue, with the previous circulating serotype (DENV1) and also sequenced the new virus, to determine the lineage of the virus. Methodology/Principal findings We studied the clinical and laboratory features of 172 adult patients with acute DENV1 (n=79) and DENV2 (n=93) infection. 65 (82.3%) of those with DENV1 and 86 (92.4%) of those with DENV2 were experiencing a secondary infection. The risk of developing dengue haemorrhagic fever (DHF) was significantly higher (=0.005, odds ratio=2.5) in those infected with DENV2 (54.8%) when compared to DENV1(32.9%), even though similar proportions of patients had a secondary dengue infection. Patients with DENV2 infection developed leakage significantly earlier (p<0.0001, median= 3, days) when compared to those with a DENV1 infection (median 5 days) and were more likely to develop significant bleeding and to require blood transfusions. Furthermore, patients with DENV2 were more likely to have significantly lower platelet counts during day 3, 4 and 5 since onset of illness. Whole genome sequencing showed that these DENV-2 isolates belonged to a cosmopolitan strain and was genetically more distant than the DENV-2 strains that circulated from 1981 to 2004 in Sri Lanka. Conclusions/significance Since this DENV2 strain appears to cause more severe forms of clinical disease, it would be important to determine variations in the virus genome or other factors that could have contributed to severe disease. Author summary Sri Lanka experienced the largest ever dengue outbreak in year 2017, which coincided with the shift of the predominant circulating dengue virus (DENV) 1 to DENV2 after 9 years. We studied the clinical and laboratory features of 172 adult patients with acute DENV1 (n=79) and DENV2 (n=93) infection. The risk of developing dengue haemorrhagic fever was significantly higher (=0.005, odds ratio=2.5) in those infected with DENV2 (54.8%) when compared to DENV1(32.9%), even though similar proportions of patients had a secondary dengue infection. Patients with DENV2 infection developed leakage significantly earlier (p<0.0001, median= 3, days) when compared to those with a DENV1 infection (median 5 days) and were more likely to develop significant bleeding. Whole genome sequencing showed that these DENV-2 isolates belonged to cosmopolitan strain and was genetically more distant to the DENV-2 strains that circulated from 1981 to 2004 in Sri Lanka." @default.
• W2804032488 created "2018-06-01" @default.
• W2804032488 creator A5004405386 @default.
• W2804032488 creator A5006304566 @default.
• W2804032488 creator A5011037605 @default.
• W2804032488 creator A5011127135 @default.
• W2804032488 creator A5017359134 @default.
• W2804032488 creator A5019259353 @default.
• W2804032488 creator A5024580422 @default.
• W2804032488 creator A5025846828 @default.
• W2804032488 creator A5033785919 @default.
• W2804032488 creator A5037643655 @default.
• W2804032488 creator A5045406707 @default.
• W2804032488 creator A5069911325 @default.
• W2804032488 creator A5076596838 @default.
• W2804032488 creator A5089478345 @default.
• W2804032488 date "2018-05-23" @default.
• W2804032488 modified "2023-09-26" @default.
• W2804032488 title "Emergence of a Dengue virus serotype 2 causing the largest ever dengue epidemic in Sri Lanka" @default.
• W2804032488 cites W1519382904 @default.
• W2804032488 cites W1991501606 @default.
• W2804032488 cites W2002619804 @default.
• W2804032488 cites W2034050258 @default.
• W2804032488 cites W2053490656 @default.
• W2804032488 cites W2104074995 @default.
• W2804032488 cites W2111222009 @default.
• W2804032488 cites W2125879085 @default.
• W2804032488 cites W2128110156 @default.
• W2804032488 cites W2131222241 @default.
• W2804032488 cites W2145629676 @default.
• W2804032488 cites W2150158172 @default.
• W2804032488 cites W2154260563 @default.
• W2804032488 cites W2162290273 @default.
• W2804032488 cites W2260392875 @default.
• W2804032488 cites W2283495904 @default.
• W2804032488 cites W2289317918 @default.
• W2804032488 cites W2464992808 @default.
• W2804032488 cites W2745642805 @default.
• W2804032488 doi "https://doi.org/10.1101/329318" @default.
• W2804032488 hasPublicationYear "2018" @default.
• W2804032488 type Work @default.
• W2804032488 sameAs 2804032488 @default.
• W2804032488 citedByCount "7" @default.
• W2804032488 countsByYear W28040324882019 @default.
• W2804032488 countsByYear W28040324882020 @default.
• W2804032488 countsByYear W28040324882021 @default.
• W2804032488 countsByYear W28040324882022 @default.
• W2804032488 crossrefType "posted-content" @default.
• W2804032488 hasAuthorship W2804032488A5004405386 @default.
• W2804032488 hasAuthorship W2804032488A5006304566 @default.
• W2804032488 hasAuthorship W2804032488A5011037605 @default.
• W2804032488 hasAuthorship W2804032488A5011127135 @default.
• W2804032488 hasAuthorship W2804032488A5017359134 @default.
• W2804032488 hasAuthorship W2804032488A5019259353 @default.
• W2804032488 hasAuthorship W2804032488A5024580422 @default.
• W2804032488 hasAuthorship W2804032488A5025846828 @default.
• W2804032488 hasAuthorship W2804032488A5033785919 @default.
• W2804032488 hasAuthorship W2804032488A5037643655 @default.
• W2804032488 hasAuthorship W2804032488A5045406707 @default.
• W2804032488 hasAuthorship W2804032488A5069911325 @default.
• W2804032488 hasAuthorship W2804032488A5076596838 @default.
• W2804032488 hasAuthorship W2804032488A5089478345 @default.
• W2804032488 hasBestOaLocation W28040324881 @default.
• W2804032488 hasConcept C10389963 @default.
• W2804032488 hasConcept C116675565 @default.
• W2804032488 hasConcept C126322002 @default.
• W2804032488 hasConcept C156957248 @default.
• W2804032488 hasConcept C159047783 @default.
• W2804032488 hasConcept C2522874641 @default.
• W2804032488 hasConcept C2549261 @default.
• W2804032488 hasConcept C2779635636 @default.
• W2804032488 hasConcept C3017649214 @default.
• W2804032488 hasConcept C3019281177 @default.
• W2804032488 hasConcept C533803919 @default.
• W2804032488 hasConcept C71924100 @default.
• W2804032488 hasConcept C86803240 @default.
• W2804032488 hasConcept C95457728 @default.
• W2804032488 hasConceptScore W2804032488C10389963 @default.
• W2804032488 hasConceptScore W2804032488C116675565 @default.
• W2804032488 hasConceptScore W2804032488C126322002 @default.
• W2804032488 hasConceptScore W2804032488C156957248 @default.
• W2804032488 hasConceptScore W2804032488C159047783 @default.
• W2804032488 hasConceptScore W2804032488C2522874641 @default.
• W2804032488 hasConceptScore W2804032488C2549261 @default.
• W2804032488 hasConceptScore W2804032488C2779635636 @default.
• W2804032488 hasConceptScore W2804032488C3017649214 @default.
• W2804032488 hasConceptScore W2804032488C3019281177 @default.
• W2804032488 hasConceptScore W2804032488C533803919 @default.
• W2804032488 hasConceptScore W2804032488C71924100 @default.
• W2804032488 hasConceptScore W2804032488C86803240 @default.
• W2804032488 hasConceptScore W2804032488C95457728 @default.
• W2804032488 hasLocation W28040324881 @default.
• W2804032488 hasOpenAccess W2804032488 @default.
• W2804032488 hasPrimaryLocation W28040324881 @default.
• W2804032488 hasRelatedWork W2008026220 @default.
• W2804032488 hasRelatedWork W2011625674 @default.
• W2804032488 hasRelatedWork W2051134904 @default.
• W2804032488 hasRelatedWork W2329860896 @default.
• W2804032488 hasRelatedWork W2342183947 @default.
• W2804032488 hasRelatedWork W2398524427 @default.

• next