FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804037648> ?p ?o ?g. }

• W2804037648 endingPage "19" @default.
• W2804037648 startingPage "8" @default.
• W2804037648 abstract "Cardiac stem/progenitor cells (CPCs) have recently emerged as a potentially transformative regenerative medicine to repair the infarcted heart. However, the limited survival of donor cells is one of the major challenges for CPC therapy. Our recent research effort on preconditioning human CPCs (hCPCs) with cobalt protoporphyrin (CoPP) indicated that sulfiredoxin-1 (SRXN1) is upregulated upon preconditioning aldehyde dehydrogenase bright hCPCs (ALDHbr-hCPCs) with CoPP. Further studies demonstrated that overexpressing SRXN1 enhanced the survival capacity for ALDHbr-hCPCs. This was associated with the up-regulation of anti-apoptotic factors, including BCL2 and BCL-xL. Meanwhile, overexpressing SRXN1 decreased the ROS generation and mitochondrial membrane potential, concomitant with the up-regulated primary antioxidant systems, such as PRDX1, PRDX3, TXNRD1, Catalase and SOD2. It was also observed that overexpressing SRXN1 increased the migration, proliferation, and cardiac differentiation of ALDHbr-hCPCs. Interestingly, SRXN1 activated the ERK/NRF2 cell survival signaling pathway, which may be the underlying mechanism through which overexpressing SRXN1 lead to protection of hCPCs against oxidative stress-induced apoptosis. Taken together, these results provide a rationale for the exploration of SRXN1 as a novel molecular target that can be used to enhance the effectiveness of cardiac stem/progenitor cell therapy for ischemic heart disease." @default.
• W2804037648 created "2018-06-01" @default.
• W2804037648 creator A5021206091 @default.
• W2804037648 creator A5031874278 @default.
• W2804037648 creator A5035430360 @default.
• W2804037648 creator A5038247623 @default.
• W2804037648 creator A5046875759 @default.
• W2804037648 creator A5056559242 @default.
• W2804037648 creator A5085639209 @default.
• W2804037648 date "2018-08-01" @default.
• W2804037648 modified "2023-09-28" @default.
• W2804037648 title "Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway" @default.
• W2804037648 cites W1510295638 @default.
• W2804037648 cites W1600346125 @default.
• W2804037648 cites W1899356937 @default.
• W2804037648 cites W1914437918 @default.
• W2804037648 cites W1963756072 @default.
• W2804037648 cites W1967693339 @default.
• W2804037648 cites W1967925595 @default.
• W2804037648 cites W1974182237 @default.
• W2804037648 cites W1979243197 @default.
• W2804037648 cites W1985042590 @default.
• W2804037648 cites W1985797014 @default.
• W2804037648 cites W1986688234 @default.
• W2804037648 cites W1992292208 @default.
• W2804037648 cites W1995091371 @default.
• W2804037648 cites W1995691676 @default.
• W2804037648 cites W2001835316 @default.
• W2804037648 cites W2009397177 @default.
• W2804037648 cites W2010368308 @default.
• W2804037648 cites W2011074645 @default.
• W2804037648 cites W2011800051 @default.
• W2804037648 cites W2013825275 @default.
• W2804037648 cites W2021110745 @default.
• W2804037648 cites W2028036560 @default.
• W2804037648 cites W2029533016 @default.
• W2804037648 cites W2036767564 @default.
• W2804037648 cites W2045982363 @default.
• W2804037648 cites W2054330377 @default.
• W2804037648 cites W2064415817 @default.
• W2804037648 cites W2068786448 @default.
• W2804037648 cites W2073656127 @default.
• W2804037648 cites W2078627344 @default.
• W2804037648 cites W2084037323 @default.
• W2804037648 cites W2087895623 @default.
• W2804037648 cites W2096650620 @default.
• W2804037648 cites W2107073759 @default.
• W2804037648 cites W2107407897 @default.
• W2804037648 cites W2110356212 @default.
• W2804037648 cites W2114931140 @default.
• W2804037648 cites W2124657837 @default.
• W2804037648 cites W2126266722 @default.
• W2804037648 cites W2130911731 @default.
• W2804037648 cites W2132312679 @default.
• W2804037648 cites W2132735690 @default.
• W2804037648 cites W2133909243 @default.
• W2804037648 cites W2141501509 @default.
• W2804037648 cites W2159653972 @default.
• W2804037648 cites W2190766406 @default.
• W2804037648 cites W2217231788 @default.
• W2804037648 cites W2254879660 @default.
• W2804037648 cites W2257790657 @default.
• W2804037648 cites W2276370059 @default.
• W2804037648 cites W2295452931 @default.
• W2804037648 cites W2299674453 @default.
• W2804037648 cites W2566958631 @default.
• W2804037648 cites W2763738314 @default.
• W2804037648 cites W811643587 @default.
• W2804037648 doi "https://doi.org/10.1016/j.freeradbiomed.2018.05.060" @default.
• W2804037648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5999586" @default.
• W2804037648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29772252" @default.
• W2804037648 hasPublicationYear "2018" @default.
• W2804037648 type Work @default.
• W2804037648 sameAs 2804037648 @default.
• W2804037648 citedByCount "31" @default.
• W2804037648 countsByYear W28040376482019 @default.
• W2804037648 countsByYear W28040376482020 @default.
• W2804037648 countsByYear W28040376482021 @default.
• W2804037648 countsByYear W28040376482022 @default.
• W2804037648 countsByYear W28040376482023 @default.
• W2804037648 crossrefType "journal-article" @default.
• W2804037648 hasAuthorship W2804037648A5021206091 @default.
• W2804037648 hasAuthorship W2804037648A5031874278 @default.
• W2804037648 hasAuthorship W2804037648A5035430360 @default.
• W2804037648 hasAuthorship W2804037648A5038247623 @default.
• W2804037648 hasAuthorship W2804037648A5046875759 @default.
• W2804037648 hasAuthorship W2804037648A5056559242 @default.
• W2804037648 hasAuthorship W2804037648A5085639209 @default.
• W2804037648 hasBestOaLocation W28040376482 @default.
• W2804037648 hasConcept C104317684 @default.
• W2804037648 hasConcept C127561419 @default.
• W2804037648 hasConcept C181199279 @default.
• W2804037648 hasConcept C185592680 @default.
• W2804037648 hasConcept C201750760 @default.
• W2804037648 hasConcept C2775838275 @default.
• W2804037648 hasConcept C2776108821 @default.
• W2804037648 hasConcept C2776151105 @default.
• W2804037648 hasConcept C2776217839 @default.

• next