FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804055708> ?p ?o ?g. }

• W2804055708 abstract "Abstract Influenza A viruses evolve rapidly to escape host immunity, such that individuals can be infected multiple times with the same subtype. The form and duration of protective immunity after each influenza infection are poorly understood. Here, we quantify the dynamics of protective immunity against influenza A virus infections by fitting individual-level mechanistic models to longitudinal serology from children and adults in a household cohort study. We find that most protection in children is explained by antibody titers measured by the hemagglutination inhibition (HI) assay. In contrast, in adults, HI antibody titers explain a smaller fraction of protection. Protection against circulating strains wanes to approximately 50% of peak levels 3.5-7 years after infection in both age groups, and wanes faster against influenza A(H3N2) than A(H1N1)pdm09. Protection against H3N2 lasts longer in adults than in children. Our results suggest that the focus of influenza antibody responses changes over time from the highly mutable hemagglutinin head to other epitopes, consistent with the immunological theory of original antigenic sin, and that this change of focus might affect protection. Additionally, we estimate that imprinting, or primary infection with a subtype of one phylogenetic group, has little to no effect on the risk of non-medically attended influenza infections in adults. We also find no evidence of long-term cross-protection between subtypes. This work underscores the need for longitudinal data on multiple components of the immune response to better understand the development of immunity and differences in susceptibility within populations." @default.
• W2804055708 created "2018-06-01" @default.
• W2804055708 creator A5023260928 @default.
• W2804055708 creator A5033989283 @default.
• W2804055708 creator A5040730521 @default.
• W2804055708 creator A5043618382 @default.
• W2804055708 creator A5044693410 @default.
• W2804055708 creator A5054744757 @default.
• W2804055708 creator A5064142468 @default.
• W2804055708 creator A5085534570 @default.
• W2804055708 creator A5086441702 @default.
• W2804055708 date "2018-05-25" @default.
• W2804055708 modified "2023-10-03" @default.
• W2804055708 title "Age-specific differences in the dynamics of protective immunity to influenza" @default.
• W2804055708 cites W1605476242 @default.
• W2804055708 cites W1925888064 @default.
• W2804055708 cites W1963590894 @default.
• W2804055708 cites W1968306957 @default.
• W2804055708 cites W1968371014 @default.
• W2804055708 cites W1982711070 @default.
• W2804055708 cites W1984416131 @default.
• W2804055708 cites W1994123792 @default.
• W2804055708 cites W1997515118 @default.
• W2804055708 cites W1997704788 @default.
• W2804055708 cites W1998170980 @default.
• W2804055708 cites W1999532513 @default.
• W2804055708 cites W2013492992 @default.
• W2804055708 cites W2053746900 @default.
• W2804055708 cites W2059684539 @default.
• W2804055708 cites W2060045669 @default.
• W2804055708 cites W2062740562 @default.
• W2804055708 cites W2065266611 @default.
• W2804055708 cites W2068592034 @default.
• W2804055708 cites W2074899179 @default.
• W2804055708 cites W2081240341 @default.
• W2804055708 cites W2093258104 @default.
• W2804055708 cites W2094273993 @default.
• W2804055708 cites W2101328014 @default.
• W2804055708 cites W2103963431 @default.
• W2804055708 cites W2106949822 @default.
• W2804055708 cites W2117278984 @default.
• W2804055708 cites W2117512155 @default.
• W2804055708 cites W2137378887 @default.
• W2804055708 cites W2143068386 @default.
• W2804055708 cites W2143521244 @default.
• W2804055708 cites W2145230724 @default.
• W2804055708 cites W2145822650 @default.
• W2804055708 cites W2146581768 @default.
• W2804055708 cites W2156622172 @default.
• W2804055708 cites W2157694241 @default.
• W2804055708 cites W2162821139 @default.
• W2804055708 cites W2168583887 @default.
• W2804055708 cites W2169180983 @default.
• W2804055708 cites W2297142125 @default.
• W2804055708 cites W2315647989 @default.
• W2804055708 cites W2557207823 @default.
• W2804055708 cites W2573825602 @default.
• W2804055708 cites W2592573144 @default.
• W2804055708 cites W2605343262 @default.
• W2804055708 cites W2730424406 @default.
• W2804055708 cites W2731524465 @default.
• W2804055708 cites W2744104561 @default.
• W2804055708 cites W2751662149 @default.
• W2804055708 cites W2763756749 @default.
• W2804055708 cites W2769478359 @default.
• W2804055708 cites W2795900571 @default.
• W2804055708 cites W2806875995 @default.
• W2804055708 cites W2889672674 @default.
• W2804055708 cites W4246234887 @default.
• W2804055708 cites W2134643332 @default.
• W2804055708 doi "https://doi.org/10.1101/330720" @default.
• W2804055708 hasPublicationYear "2018" @default.
• W2804055708 type Work @default.
• W2804055708 sameAs 2804055708 @default.
• W2804055708 citedByCount "3" @default.
• W2804055708 countsByYear W28040557082018 @default.
• W2804055708 countsByYear W28040557082019 @default.
• W2804055708 crossrefType "posted-content" @default.
• W2804055708 hasAuthorship W2804055708A5023260928 @default.
• W2804055708 hasAuthorship W2804055708A5033989283 @default.
• W2804055708 hasAuthorship W2804055708A5040730521 @default.
• W2804055708 hasAuthorship W2804055708A5043618382 @default.
• W2804055708 hasAuthorship W2804055708A5044693410 @default.
• W2804055708 hasAuthorship W2804055708A5054744757 @default.
• W2804055708 hasAuthorship W2804055708A5064142468 @default.
• W2804055708 hasAuthorship W2804055708A5085534570 @default.
• W2804055708 hasAuthorship W2804055708A5086441702 @default.
• W2804055708 hasBestOaLocation W28040557081 @default.
• W2804055708 hasConcept C159047783 @default.
• W2804055708 hasConcept C159654299 @default.
• W2804055708 hasConcept C180915046 @default.
• W2804055708 hasConcept C182072434 @default.
• W2804055708 hasConcept C203014093 @default.
• W2804055708 hasConcept C22070199 @default.
• W2804055708 hasConcept C22889606 @default.
• W2804055708 hasConcept C2522874641 @default.
• W2804055708 hasConcept C2777546802 @default.
• W2804055708 hasConcept C2778692840 @default.
• W2804055708 hasConcept C2779341262 @default.
• W2804055708 hasConcept C32611913 @default.

• next