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- W2804056263 abstract "Generation of oxidative stress emerges as an anticancer strategy. This strategy is based on the fact that cancer cells have a higher intrinsic basal oxidative stress than normal cells. Thus, a drug generating additional oxidative stress or inhibiting the antioxidant system will exert a selective cytotoxicity towards cancer cells without affecting normal ones. This is the case of vitamin C (ascorbic acid), a natural molecule with pro-oxidant properties at high doses that has been recently repurposed for promising anticancer activity. We have performed “Redoxome” proteomics approach and bioinformatics analysis to decipher the underlying mechanisms of vitamin C redox-based anticancer activity toward breast cancer, in vitro and in vivo and to identify predicting biomarkers involved in the sensitivity / resistance of breast cancer cells to this molecule. This work should provide biological basis for better conceiving the anticancer application of vitamin C, alone or in combinations with other redox-modulating molecules to synergistically enhance the anticancer effect and bypass the drug resistance, thus, opening new avenues for redox-based anticancer therapy." @default.
- W2804056263 created "2018-06-01" @default.
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- W2804056263 date "2018-05-01" @default.
- W2804056263 modified "2023-09-29" @default.
- W2804056263 title "Investigating redox-based anticancer mechanisms of vitamin C" @default.
- W2804056263 doi "https://doi.org/10.1016/j.freeradbiomed.2018.04.518" @default.
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