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- W2804069488 abstract "Although inhaled therapies are typically preferred for the maintenance treatment of obstructive lung diseases, oral drug therapies can also play valuable roles. The most commonly used oral agents are phosphodiesterase inhibitors, theophylline, macrolides, leukotriene modifiers, and mucoactive agents. Advantages of these oral agents include the unique pharmacologic mechanisms of action, the avoidance of the challenges of proper inhalational lung administration, and, in most instances, relative drug cost. For many of these agents, anti-inflammatory or immunomodulatory effects are the predominant pharmacologic mechanism that each provides clinical benefit, with the exception of guaifenesin. In addition, theophylline, leukotriene modifiers, chronic macrolides, phosphodiesterase inhibitors, and N-acetylcysteine have been shown to decrease exacerbations in obstructive lung disease. Fairly rapid bronchodilation occurs with the phosphodiesterase inhibitors, theophylline, and leukotriene modifiers, although less than that achieved with inhaled therapies. The clinical roles of phosphodiesterase inhibitors, specifically roflumilast, and macrolides continues to be defined today, whereas the roles theophylline and leukotriene modifiers have probably been largely delineated. Azithromycin is the principal macrolide used chronically for obstructive lung diseases, especially COPD. Although guaifenesin is used widely, its effectiveness is unclear, whereas N-acetylcysteine currently has strong evidence supporting a decreased risk of COPD exacerbations. Mucolytic agents like N-acetylcysteine are used more widely outside the United States in obstructive lung diseases." @default.
- W2804069488 created "2018-06-01" @default.
- W2804069488 creator A5089261970 @default.
- W2804069488 date "2018-05-24" @default.
- W2804069488 modified "2023-10-10" @default.
- W2804069488 title "Clinical Pharmacology of Oral Maintenance Therapies for Obstructive Lung Diseases" @default.
- W2804069488 cites W1495900873 @default.
- W2804069488 cites W1530606127 @default.
- W2804069488 cites W1531474084 @default.
- W2804069488 cites W1703274786 @default.
- W2804069488 cites W1782812324 @default.
- W2804069488 cites W1964552738 @default.
- W2804069488 cites W1965012610 @default.
- W2804069488 cites W1967930073 @default.
- W2804069488 cites W1971448764 @default.
- W2804069488 cites W1971574036 @default.
- W2804069488 cites W1976021567 @default.
- W2804069488 cites W1976722278 @default.
- W2804069488 cites W1977227712 @default.
- W2804069488 cites W1977449486 @default.
- W2804069488 cites W1989508185 @default.
- W2804069488 cites W1992318486 @default.
- W2804069488 cites W1995818471 @default.
- W2804069488 cites W1995976051 @default.
- W2804069488 cites W1996998116 @default.
- W2804069488 cites W1999387516 @default.
- W2804069488 cites W2000956292 @default.
- W2804069488 cites W2001965102 @default.
- W2804069488 cites W2002955835 @default.
- W2804069488 cites W2003466206 @default.
- W2804069488 cites W2003988701 @default.
- W2804069488 cites W2005475888 @default.
- W2804069488 cites W2006559204 @default.
- W2804069488 cites W2007611048 @default.
- W2804069488 cites W2013407710 @default.
- W2804069488 cites W2014133471 @default.
- W2804069488 cites W2026549814 @default.
- W2804069488 cites W2029251290 @default.
- W2804069488 cites W2030331302 @default.
- W2804069488 cites W2031954841 @default.
- W2804069488 cites W2044782575 @default.
- W2804069488 cites W2045749557 @default.
- W2804069488 cites W2050358940 @default.
- W2804069488 cites W2052225778 @default.
- W2804069488 cites W2056406352 @default.
- W2804069488 cites W2058402128 @default.
- W2804069488 cites W2061421540 @default.
- W2804069488 cites W2064279724 @default.
- W2804069488 cites W2064421576 @default.
- W2804069488 cites W2066971711 @default.
- W2804069488 cites W2069078228 @default.
- W2804069488 cites W2070508196 @default.
- W2804069488 cites W2072217715 @default.
- W2804069488 cites W2073802634 @default.
- W2804069488 cites W2075419966 @default.
- W2804069488 cites W2086055259 @default.
- W2804069488 cites W2088700715 @default.
- W2804069488 cites W2089955895 @default.
- W2804069488 cites W2090648579 @default.
- W2804069488 cites W2092531447 @default.
- W2804069488 cites W2096373158 @default.
- W2804069488 cites W2096852837 @default.
- W2804069488 cites W2097443821 @default.
- W2804069488 cites W2098115046 @default.
- W2804069488 cites W2102590607 @default.
- W2804069488 cites W2107014409 @default.
- W2804069488 cites W2108424624 @default.
- W2804069488 cites W2109205500 @default.
- W2804069488 cites W2111983640 @default.
- W2804069488 cites W2112215977 @default.
- W2804069488 cites W2114648775 @default.
- W2804069488 cites W2119425860 @default.
- W2804069488 cites W2121159616 @default.
- W2804069488 cites W2123597424 @default.
- W2804069488 cites W2124369942 @default.
- W2804069488 cites W2125361989 @default.
- W2804069488 cites W2125710315 @default.
- W2804069488 cites W2125901283 @default.
- W2804069488 cites W2130770638 @default.
- W2804069488 cites W2131296354 @default.
- W2804069488 cites W2134508367 @default.
- W2804069488 cites W2135250308 @default.
- W2804069488 cites W2137716849 @default.
- W2804069488 cites W2139137636 @default.
- W2804069488 cites W2146887625 @default.
- W2804069488 cites W2149554320 @default.
- W2804069488 cites W2151599229 @default.
- W2804069488 cites W2154553542 @default.
- W2804069488 cites W2154699386 @default.
- W2804069488 cites W2156953901 @default.
- W2804069488 cites W2158608977 @default.
- W2804069488 cites W2158976881 @default.
- W2804069488 cites W2160381299 @default.
- W2804069488 cites W2163841350 @default.
- W2804069488 cites W2164548092 @default.
- W2804069488 cites W2171787820 @default.
- W2804069488 cites W2172296213 @default.
- W2804069488 cites W2172414863 @default.