FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804070615> ?p ?o ?g. }

• W2804070615 abstract "Pathological proliferative retinopathy is the most common cause of blindness in patients of all ages worldwide. Investigation of the molecular mechanisms underlying pathological retina neovascularization is critical to the development of new therapeutic strategies. In the current study, we investigated the effect of macrophage or endothelial cell adenosine receptor 2A (A 2A R) deletion in pathological retinal vascular growth, and further explored the potential mechanism. Our results showed that: (1) A 2A R expression was localized to retinal vessels and was markedly induced in pathological neovascularization tufts in a mouse model of oxygen-induced proliferative retinopathy (OIR) (Figure A); (2) endothelial cell, but not macrophage, -specific A 2A R deletion significantly decreased pathological neovascularization in the mouse OIR model (Figure B);. The levels of glycolytic enzymes, angiogenic factors and lactate secretion were markedly reduced in retina of endothelial cell-specific A 2A R knockout mice; (3) in human retinal microvascular endothelial cells (HRMECs), hypoxia markedly induced the expression of A 2A R, but not A 1 R, A 2B R and A 3 R, by activating HIF-2α. Deletion or blockade of A 2A R by small interfering RNA (siRNA) or antagonist ZM241385 decreased hypoxia or adenosine-induced glycolytic enzyme expression, lactate secretion and cell proliferation via suppression of the cAMP/PKA/CREB/HIF-1α pathway; (4) blockade of glycolysis by 3PO or 2-DG abolished the adenosine-induced HRMEC proliferation under hypoxic conditions. Taken together, we have demonstrated a critical role of endothelial cell A 2A R in promoting pathological vascular development and revealed a novel glycolysis-driven mechanism for endothelial cell A 2A R-mediated pathological angiogenesis in proliferative retinopathy. Thus, A 2A R is a promising therapeutic target in the treatment of proliferative retinopathy." @default.
• W2804070615 created "2018-06-01" @default.
• W2804070615 creator A5003537990 @default.
• W2804070615 creator A5003946127 @default.
• W2804070615 creator A5044690473 @default.
• W2804070615 creator A5046465689 @default.
• W2804070615 creator A5066102428 @default.
• W2804070615 creator A5069763363 @default.
• W2804070615 creator A5069805999 @default.
• W2804070615 creator A5080905237 @default.
• W2804070615 creator A5081914693 @default.
• W2804070615 date "2016-05-01" @default.
• W2804070615 modified "2023-09-27" @default.
• W2804070615 title "Abstract 177: Adenosine Receptor 2A-mediated Endothelial Glycolysis Critically Contributes to Pathological Angiogenesis of Retina" @default.
• W2804070615 doi "https://doi.org/10.1161/atvb.36.suppl_1.177" @default.
• W2804070615 hasPublicationYear "2016" @default.
• W2804070615 type Work @default.
• W2804070615 sameAs 2804070615 @default.
• W2804070615 citedByCount "0" @default.
• W2804070615 crossrefType "journal-article" @default.
• W2804070615 hasAuthorship W2804070615A5003537990 @default.
• W2804070615 hasAuthorship W2804070615A5003946127 @default.
• W2804070615 hasAuthorship W2804070615A5044690473 @default.
• W2804070615 hasAuthorship W2804070615A5046465689 @default.
• W2804070615 hasAuthorship W2804070615A5066102428 @default.
• W2804070615 hasAuthorship W2804070615A5069763363 @default.
• W2804070615 hasAuthorship W2804070615A5069805999 @default.
• W2804070615 hasAuthorship W2804070615A5080905237 @default.
• W2804070615 hasAuthorship W2804070615A5081914693 @default.
• W2804070615 hasConcept C123012128 @default.
• W2804070615 hasConcept C126322002 @default.
• W2804070615 hasConcept C134018914 @default.
• W2804070615 hasConcept C169760540 @default.
• W2804070615 hasConcept C178790620 @default.
• W2804070615 hasConcept C185592680 @default.
• W2804070615 hasConcept C20251656 @default.
• W2804070615 hasConcept C202751555 @default.
• W2804070615 hasConcept C2776991684 @default.
• W2804070615 hasConcept C2777093970 @default.
• W2804070615 hasConcept C2778271429 @default.
• W2804070615 hasConcept C2778376644 @default.
• W2804070615 hasConcept C2779234561 @default.
• W2804070615 hasConcept C2779918416 @default.
• W2804070615 hasConcept C2780394083 @default.
• W2804070615 hasConcept C2780827179 @default.
• W2804070615 hasConcept C502942594 @default.
• W2804070615 hasConcept C540031477 @default.
• W2804070615 hasConcept C54355233 @default.
• W2804070615 hasConcept C55493867 @default.
• W2804070615 hasConcept C62231903 @default.
• W2804070615 hasConcept C71924100 @default.
• W2804070615 hasConcept C7836513 @default.
• W2804070615 hasConcept C86803240 @default.
• W2804070615 hasConcept C95444343 @default.
• W2804070615 hasConceptScore W2804070615C123012128 @default.
• W2804070615 hasConceptScore W2804070615C126322002 @default.
• W2804070615 hasConceptScore W2804070615C134018914 @default.
• W2804070615 hasConceptScore W2804070615C169760540 @default.
• W2804070615 hasConceptScore W2804070615C178790620 @default.
• W2804070615 hasConceptScore W2804070615C185592680 @default.
• W2804070615 hasConceptScore W2804070615C20251656 @default.
• W2804070615 hasConceptScore W2804070615C202751555 @default.
• W2804070615 hasConceptScore W2804070615C2776991684 @default.
• W2804070615 hasConceptScore W2804070615C2777093970 @default.
• W2804070615 hasConceptScore W2804070615C2778271429 @default.
• W2804070615 hasConceptScore W2804070615C2778376644 @default.
• W2804070615 hasConceptScore W2804070615C2779234561 @default.
• W2804070615 hasConceptScore W2804070615C2779918416 @default.
• W2804070615 hasConceptScore W2804070615C2780394083 @default.
• W2804070615 hasConceptScore W2804070615C2780827179 @default.
• W2804070615 hasConceptScore W2804070615C502942594 @default.
• W2804070615 hasConceptScore W2804070615C540031477 @default.
• W2804070615 hasConceptScore W2804070615C54355233 @default.
• W2804070615 hasConceptScore W2804070615C55493867 @default.
• W2804070615 hasConceptScore W2804070615C62231903 @default.
• W2804070615 hasConceptScore W2804070615C71924100 @default.
• W2804070615 hasConceptScore W2804070615C7836513 @default.
• W2804070615 hasConceptScore W2804070615C86803240 @default.
• W2804070615 hasConceptScore W2804070615C95444343 @default.
• W2804070615 hasLocation W28040706151 @default.
• W2804070615 hasOpenAccess W2804070615 @default.
• W2804070615 hasPrimaryLocation W28040706151 @default.
• W2804070615 hasRelatedWork W1827160543 @default.
• W2804070615 hasRelatedWork W2008620428 @default.
• W2804070615 hasRelatedWork W2009716896 @default.
• W2804070615 hasRelatedWork W2060824010 @default.
• W2804070615 hasRelatedWork W2073741182 @default.
• W2804070615 hasRelatedWork W2078072215 @default.
• W2804070615 hasRelatedWork W2085129988 @default.
• W2804070615 hasRelatedWork W2108525961 @default.
• W2804070615 hasRelatedWork W2121099709 @default.
• W2804070615 hasRelatedWork W2124156250 @default.
• W2804070615 hasRelatedWork W2132036488 @default.
• W2804070615 hasRelatedWork W2293749951 @default.
• W2804070615 hasRelatedWork W2757869262 @default.
• W2804070615 hasRelatedWork W2887371331 @default.
• W2804070615 hasRelatedWork W2902057094 @default.
• W2804070615 hasRelatedWork W2910137809 @default.
• W2804070615 hasRelatedWork W2999113843 @default.
• W2804070615 hasRelatedWork W3024770843 @default.

• next