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- W2804089284 endingPage "1659" @default.
- W2804089284 startingPage "1649" @default.
- W2804089284 abstract "The gastrointestinal tract harbors the largest microbiota load in the human body, hence maintaining a delicate balance between immunity against invading pathogens and tolerance toward commensal. Such immune equilibrium, or intestinal homeostasis, is conducted by a tight regulation and cooperation of the different branches of the immune system, including the innate and the adaptive immune system. However, several factors affect this delicate equilibrium, ultimately leading to gastrointestinal disorders including inflammatory bowel disease. Therefore, here we decided to review the currently available information about innate immunity lymphocyte subsets playing a role in intestinal inflammation. Intestinal innate lymphocytes are composed of intraepithelial lymphocytes (IELs) and lamina propria innate lymphoid cells (ILCs). While IELs can be divided into natural or induced, ILCs can be classified into type 1, 2, or 3, resembling, respectively, the properties of TH1, TH2, or TH17 adaptive lymphocytes. Noteworthy, the phenotype and function of both IELs and ILCs are disrupted under inflammatory conditions, where they help to exacerbate intestinal immune responses. The modulation of both IELs and ILCs to control intestinal inflammatory responses represents a major challenge, as they provide tight regulation among the epithelium, the microbiota, and the adaptive immune system. An improved understanding of the innate immunity mechanisms involved in gastrointestinal inflammation would therefore aid in the diagnosis and further treatment of gastrointestinal inflammatory disorders." @default.
- W2804089284 created "2018-06-01" @default.
- W2804089284 creator A5051403366 @default.
- W2804089284 creator A5056264715 @default.
- W2804089284 creator A5086629019 @default.
- W2804089284 date "2018-05-18" @default.
- W2804089284 modified "2023-10-17" @default.
- W2804089284 title "The Innate Immune System in the Gastrointestinal Tract: Role of Intraepithelial Lymphocytes and Lamina Propria Innate Lymphoid Cells in Intestinal Inflammation" @default.
- W2804089284 cites W1480620136 @default.
- W2804089284 cites W1495055286 @default.
- W2804089284 cites W1500160410 @default.
- W2804089284 cites W1500518582 @default.
- W2804089284 cites W1511705708 @default.
- W2804089284 cites W1531920134 @default.
- W2804089284 cites W1535586386 @default.
- W2804089284 cites W1559758724 @default.
- W2804089284 cites W1579193869 @default.
- W2804089284 cites W1585929942 @default.
- W2804089284 cites W1595949461 @default.
- W2804089284 cites W1787801518 @default.
- W2804089284 cites W1809380737 @default.
- W2804089284 cites W1828539496 @default.
- W2804089284 cites W1828796065 @default.
- W2804089284 cites W1871057772 @default.
- W2804089284 cites W1895719805 @default.
- W2804089284 cites W1942756352 @default.
- W2804089284 cites W1968818081 @default.
- W2804089284 cites W1970158367 @default.
- W2804089284 cites W1975251775 @default.
- W2804089284 cites W1975521617 @default.
- W2804089284 cites W1977475597 @default.
- W2804089284 cites W1978311073 @default.
- W2804089284 cites W1978615362 @default.
- W2804089284 cites W1979364731 @default.
- W2804089284 cites W1979530431 @default.
- W2804089284 cites W1981714996 @default.
- W2804089284 cites W1982371934 @default.
- W2804089284 cites W1989156064 @default.
- W2804089284 cites W1992979350 @default.
- W2804089284 cites W1993734178 @default.
- W2804089284 cites W1995269663 @default.
- W2804089284 cites W1999795586 @default.
- W2804089284 cites W2002307060 @default.
- W2804089284 cites W2002568513 @default.
- W2804089284 cites W2002629258 @default.
- W2804089284 cites W2006711580 @default.
- W2804089284 cites W2008926589 @default.
- W2804089284 cites W2016522268 @default.
- W2804089284 cites W2016680738 @default.
- W2804089284 cites W2017376197 @default.
- W2804089284 cites W2021533010 @default.
- W2804089284 cites W2021929390 @default.
- W2804089284 cites W2022387897 @default.
- W2804089284 cites W2024183493 @default.
- W2804089284 cites W2026520810 @default.
- W2804089284 cites W2029529774 @default.
- W2804089284 cites W2030222602 @default.
- W2804089284 cites W2040610974 @default.
- W2804089284 cites W2042944197 @default.
- W2804089284 cites W2047303696 @default.
- W2804089284 cites W2049236969 @default.
- W2804089284 cites W2051465794 @default.
- W2804089284 cites W2055912677 @default.
- W2804089284 cites W2056426915 @default.
- W2804089284 cites W2058504434 @default.
- W2804089284 cites W2060249232 @default.
- W2804089284 cites W2065638957 @default.
- W2804089284 cites W2070319044 @default.
- W2804089284 cites W2071924440 @default.
- W2804089284 cites W2072167907 @default.
- W2804089284 cites W2077157308 @default.
- W2804089284 cites W2078621117 @default.
- W2804089284 cites W2079683856 @default.
- W2804089284 cites W2083089709 @default.
- W2804089284 cites W2089025967 @default.
- W2804089284 cites W2089159776 @default.
- W2804089284 cites W2091270259 @default.
- W2804089284 cites W2091674262 @default.
- W2804089284 cites W2093250647 @default.
- W2804089284 cites W2094932532 @default.
- W2804089284 cites W2095710388 @default.
- W2804089284 cites W2098214917 @default.
- W2804089284 cites W2100866502 @default.
- W2804089284 cites W2100883408 @default.
- W2804089284 cites W2107066107 @default.
- W2804089284 cites W2114998019 @default.
- W2804089284 cites W2115252831 @default.
- W2804089284 cites W2116551829 @default.
- W2804089284 cites W2116563166 @default.
- W2804089284 cites W2117547859 @default.
- W2804089284 cites W2117727476 @default.
- W2804089284 cites W2122240592 @default.
- W2804089284 cites W2124282397 @default.
- W2804089284 cites W2124499950 @default.
- W2804089284 cites W2128394626 @default.
- W2804089284 cites W2131204388 @default.
- W2804089284 cites W2133765154 @default.
- W2804089284 cites W2136221987 @default.