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• W2804095992 abstract "The inhibition of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) potentially represents a new treatment option for malaria, as P. falciparum relies entirely on a de novo pyrimidine biosynthetic pathway for survival. Herein, we report a series of pyrimidone derivatives as novel inhibitors of PfDHODH. The most potent compound, 26, showed high inhibition activity against PfDHODH (IC50 = 23 nM), with >400-fold species selectivity over human dihydroorotate dehydrogenase (hDHODH). The brand-new inhibitor scaffold targeting PfDHODH reported in this work may lead to the discovery of new antimalarial agents." @default.
• W2804095992 created "2018-06-01" @default.
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• W2804095992 date "2018-05-24" @default.
• W2804095992 modified "2023-09-25" @default.
• W2804095992 title "Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase" @default.
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• W2804095992 doi "https://doi.org/10.3390/molecules23061254" @default.
• W2804095992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6099574" @default.
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