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- W2804111335 abstract "Bone marrow (BM) clots are routinely sampled in aspiration tests, and their sections are prepared for histological observation by hematoxylin and eosin (H&E) staining. However, H&E-stained sections are considered less informative than those stained by the May-Grünwald Giemsa (M-G) stain; thus, diagnosis using H&E-stained clot samples is challenging for pathologists. In fact, the diagnostic evaluation is limited to the observation of cellular morphology and the myeloid-erythroid cell ratio. Pathologists leave cellular observation to laboratory hematologists, who generally use M-G staining. In this chapter, the utility of bone marrow clot specimens for diagnosis by H&E staining is reviewed. Specifically, the review provides a descriptive and illustrative explanation of the diagnosis of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myelodysplastic syndrome/myelocytic proliferative neoplasm (MDS/MPN) and demonstrates the possibility of diagnosis on the basis of the characteristic features of blast cells. Clot specimens appear to be useful for the diagnosis of hematopoietic dysplasia by pathologists, and this approach can provide more informative findings for hematologists." @default.
- W2804111335 created "2018-06-01" @default.
- W2804111335 creator A5072214554 @default.
- W2804111335 date "2018-05-16" @default.
- W2804111335 modified "2023-10-18" @default.
- W2804111335 title "Cytopathology of MDS/MPN and AML by H&E Staining" @default.
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- W2804111335 doi "https://doi.org/10.5772/intechopen.71567" @default.
- W2804111335 hasPublicationYear "2018" @default.
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