FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804150306> ?p ?o ?g. }

• W2804150306 endingPage "747" @default.
• W2804150306 startingPage "741" @default.
• W2804150306 abstract "Aim: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. It appears that polymorphisms in OPRM1 may affect the efficacy of methadone maintenance treatment (MMT). Objective: Our purpose was to identify all relevant published papers dealing with the impact ofOPRM1's SNPs on MMT's efficacy and to summarize results in order to evaluate the relevance of conducting pretherapeutic genotyping in opioid addicts prior to the onset of MMT. Methods: MEDLINE, PsychINFO and Scopus databases were systematically searched up to 1 January 2018 with no year restrictions using the following keyword combination (MMT) AND (mu or OPRM or mu opioid receptors or SNP or polymorphism or gene). Endpoint of the included studies had to be the impact of OPRM1 gene polymorphisms on the efficacy of MMT and/or methadone required doses during MMT. All abstracts were reviewed to assess papers’ relevance. Studies conducted on animals and duplicate papers were excluded. Results: Our literature search identified 438 articles. Eight of them were included in our systematic review. The total number of included participants was equal to 2170, of whom 1718 underwent MMT. One study reported results of a randomized controlled trial. Three were designed as case–control studies and four as cross-sectional studies. rs1799971 (A118G) was the most studied allele. Results were divergent. Other SNPs might affect MMT's efficacy, however they were scarcely studied. Conclusion: Genotyping patients with opioid-related use disorders is a promising way to reach a better outcome in patients willing to be on MMT. Focusing on OPRM1 solely should be balanced since polymorphisms in other genes implicated in methadone pharmacodynamics and/or pharmacokinetics may conjunctly affect the efficacy of MMT. Recommendations cannot be enunciated for the moment." @default.
• W2804150306 created "2018-06-01" @default.
• W2804150306 creator A5049302873 @default.
• W2804150306 creator A5066559217 @default.
• W2804150306 creator A5085513816 @default.
• W2804150306 date "2018-06-01" @default.
• W2804150306 modified "2023-10-01" @default.
• W2804150306 title "The impact of <i>OPRM1</i>'s genetic polymorphisms on methadone maintenance treatment in opioid addicts: a systematic review" @default.
• W2804150306 cites W1971140635 @default.
• W2804150306 cites W1996783118 @default.
• W2804150306 cites W2015937282 @default.
• W2804150306 cites W2023090750 @default.
• W2804150306 cites W2023680401 @default.
• W2804150306 cites W2028724473 @default.
• W2804150306 cites W2031248731 @default.
• W2804150306 cites W2053466984 @default.
• W2804150306 cites W2055927684 @default.
• W2804150306 cites W2061254685 @default.
• W2804150306 cites W2073014088 @default.
• W2804150306 cites W2102675531 @default.
• W2804150306 cites W2104423611 @default.
• W2804150306 cites W2115239219 @default.
• W2804150306 cites W2115919908 @default.
• W2804150306 cites W2125943141 @default.
• W2804150306 cites W2148975102 @default.
• W2804150306 cites W2151827878 @default.
• W2804150306 cites W2152506996 @default.
• W2804150306 cites W2152914376 @default.
• W2804150306 cites W2154792955 @default.
• W2804150306 cites W2163268436 @default.
• W2804150306 cites W2291203958 @default.
• W2804150306 cites W2298840448 @default.
• W2804150306 cites W2530888430 @default.
• W2804150306 cites W2562550503 @default.
• W2804150306 cites W2581829687 @default.
• W2804150306 cites W2588491432 @default.
• W2804150306 cites W2607675069 @default.
• W2804150306 cites W2738777709 @default.
• W2804150306 cites W2762029726 @default.
• W2804150306 cites W2770647043 @default.
• W2804150306 cites W2773716518 @default.
• W2804150306 cites W2780782168 @default.
• W2804150306 cites W2793674530 @default.
• W2804150306 doi "https://doi.org/10.2217/pgs-2018-0017" @default.
• W2804150306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29785888" @default.
• W2804150306 hasPublicationYear "2018" @default.
• W2804150306 type Work @default.
• W2804150306 sameAs 2804150306 @default.
• W2804150306 citedByCount "9" @default.
• W2804150306 countsByYear W28041503062019 @default.
• W2804150306 countsByYear W28041503062020 @default.
• W2804150306 countsByYear W28041503062021 @default.
• W2804150306 countsByYear W28041503062022 @default.
• W2804150306 crossrefType "journal-article" @default.
• W2804150306 hasAuthorship W2804150306A5049302873 @default.
• W2804150306 hasAuthorship W2804150306A5066559217 @default.
• W2804150306 hasAuthorship W2804150306A5085513816 @default.
• W2804150306 hasConcept C104317684 @default.
• W2804150306 hasConcept C118552586 @default.
• W2804150306 hasConcept C126322002 @default.
• W2804150306 hasConcept C135763542 @default.
• W2804150306 hasConcept C153209595 @default.
• W2804150306 hasConcept C170493617 @default.
• W2804150306 hasConcept C170734499 @default.
• W2804150306 hasConcept C2778767360 @default.
• W2804150306 hasConcept C2778903061 @default.
• W2804150306 hasConcept C2778949969 @default.
• W2804150306 hasConcept C2781063702 @default.
• W2804150306 hasConcept C31467283 @default.
• W2804150306 hasConcept C48856860 @default.
• W2804150306 hasConcept C54355233 @default.
• W2804150306 hasConcept C60644358 @default.
• W2804150306 hasConcept C71924100 @default.
• W2804150306 hasConcept C86803240 @default.
• W2804150306 hasConcept C95190672 @default.
• W2804150306 hasConcept C98274493 @default.
• W2804150306 hasConceptScore W2804150306C104317684 @default.
• W2804150306 hasConceptScore W2804150306C118552586 @default.
• W2804150306 hasConceptScore W2804150306C126322002 @default.
• W2804150306 hasConceptScore W2804150306C135763542 @default.
• W2804150306 hasConceptScore W2804150306C153209595 @default.
• W2804150306 hasConceptScore W2804150306C170493617 @default.
• W2804150306 hasConceptScore W2804150306C170734499 @default.
• W2804150306 hasConceptScore W2804150306C2778767360 @default.
• W2804150306 hasConceptScore W2804150306C2778903061 @default.
• W2804150306 hasConceptScore W2804150306C2778949969 @default.
• W2804150306 hasConceptScore W2804150306C2781063702 @default.
• W2804150306 hasConceptScore W2804150306C31467283 @default.
• W2804150306 hasConceptScore W2804150306C48856860 @default.
• W2804150306 hasConceptScore W2804150306C54355233 @default.
• W2804150306 hasConceptScore W2804150306C60644358 @default.
• W2804150306 hasConceptScore W2804150306C71924100 @default.
• W2804150306 hasConceptScore W2804150306C86803240 @default.
• W2804150306 hasConceptScore W2804150306C95190672 @default.
• W2804150306 hasConceptScore W2804150306C98274493 @default.
• W2804150306 hasIssue "8" @default.
• W2804150306 hasLocation W28041503061 @default.
• W2804150306 hasLocation W28041503062 @default.

• next