FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804154027> ?p ?o ?g. }

• W2804154027 endingPage "1631" @default.
• W2804154027 startingPage "1627" @default.
• W2804154027 abstract "Background: Hepatocellular carcinoma (HCC) is the fifth most diagnosed cancer and the third leading cause of cancer-related death. sorafenib is used as a standard therapy to treat HCC. mesenchymal stromal cells (MSCs) have also been used to suppress HCC. Here we investigate the development of a xenograft model of liver cancer to study the homing of hpMSC-GFP cells, tumor kinetics and molecular characterizations of HCC. Methods: To create xenograft models of HCC, HepG2 cell lines were inoculated into the flanks of 9 nude mice bilaterally. Animals were then divided into three groups: the first group received hpMSC-GFP systemically, the second received intra-tumoral hpMSC-GFP and the third received PBS. The first two groups were sacrificed after 72 hours of MSCs injection but the third group was followed up for forty days. One tumor from each animal was then transferred to formalin buffer for H&E staining and immunohistochemistry analysis (KI67 and CD34), and the other tumor was used for ex-vivo imaging. Blood samples were taken from all subjects before sacrificing them. Results: Histopathological fidelity of heterotopic HePG2 xenograft models to human HCC tumors was demonstrated. Biochemical evaluation suggested the health of the animal’s liver and kidneys. Ex-vivo imaging illustrated homing of more hpMSC-GFP cells in tumor tissues derived from the group receiving intra-tumoral hpMSC-GFP. Conclusion: A standard method was used to inoculate tumor cells and the intervention was shown to be safe to liver and kidneys. Local injection of MSCs can be used as cell therapy to fight neoplasms." @default.
• W2804154027 created "2018-06-01" @default.
• W2804154027 creator A5012295314 @default.
• W2804154027 creator A5042572667 @default.
• W2804154027 creator A5044453202 @default.
• W2804154027 creator A5048293762 @default.
• W2804154027 creator A5056967767 @default.
• W2804154027 creator A5060689668 @default.
• W2804154027 creator A5065368311 @default.
• W2804154027 creator A5068730334 @default.
• W2804154027 creator A5074694548 @default.
• W2804154027 creator A5070625353 @default.
• W2804154027 date "2018-06-25" @default.
• W2804154027 modified "2023-10-16" @default.
• W2804154027 title "Characterization and Validation of Hepatocellular Carcinoma (HCC) Xenograft tumor as a Suitable Liver Cancer Model forPreclinical Mesenchymal Stem Cell Studies" @default.
• W2804154027 cites W1124790770 @default.
• W2804154027 cites W1484083850 @default.
• W2804154027 cites W1550667671 @default.
• W2804154027 cites W1983734516 @default.
• W2804154027 cites W1985985259 @default.
• W2804154027 cites W2027529028 @default.
• W2804154027 cites W2035087003 @default.
• W2804154027 cites W2061164005 @default.
• W2804154027 cites W2078369117 @default.
• W2804154027 cites W2108619393 @default.
• W2804154027 cites W2137052325 @default.
• W2804154027 cites W2155127143 @default.
• W2804154027 cites W2174822994 @default.
• W2804154027 cites W2185164056 @default.
• W2804154027 cites W2619032233 @default.
• W2804154027 cites W2917837889 @default.
• W2804154027 doi "https://doi.org/10.22034/apjcp.2018.19.6.1627" @default.
• W2804154027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6103601" @default.
• W2804154027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29936790" @default.
• W2804154027 hasPublicationYear "2018" @default.
• W2804154027 type Work @default.
• W2804154027 sameAs 2804154027 @default.
• W2804154027 citedByCount "11" @default.
• W2804154027 countsByYear W28041540272019 @default.
• W2804154027 countsByYear W28041540272020 @default.
• W2804154027 countsByYear W28041540272022 @default.
• W2804154027 crossrefType "journal-article" @default.
• W2804154027 hasAuthorship W2804154027A5012295314 @default.
• W2804154027 hasAuthorship W2804154027A5042572667 @default.
• W2804154027 hasAuthorship W2804154027A5044453202 @default.
• W2804154027 hasAuthorship W2804154027A5048293762 @default.
• W2804154027 hasAuthorship W2804154027A5056967767 @default.
• W2804154027 hasAuthorship W2804154027A5060689668 @default.
• W2804154027 hasAuthorship W2804154027A5065368311 @default.
• W2804154027 hasAuthorship W2804154027A5068730334 @default.
• W2804154027 hasAuthorship W2804154027A5070625353 @default.
• W2804154027 hasAuthorship W2804154027A5074694548 @default.
• W2804154027 hasConcept C10205521 @default.
• W2804154027 hasConcept C121608353 @default.
• W2804154027 hasConcept C126322002 @default.
• W2804154027 hasConcept C142724271 @default.
• W2804154027 hasConcept C150903083 @default.
• W2804154027 hasConcept C151872237 @default.
• W2804154027 hasConcept C18903297 @default.
• W2804154027 hasConcept C198826908 @default.
• W2804154027 hasConcept C204232928 @default.
• W2804154027 hasConcept C207001950 @default.
• W2804154027 hasConcept C26291073 @default.
• W2804154027 hasConcept C2776231280 @default.
• W2804154027 hasConcept C2778019345 @default.
• W2804154027 hasConcept C2778695046 @default.
• W2804154027 hasConcept C28328180 @default.
• W2804154027 hasConcept C502942594 @default.
• W2804154027 hasConcept C54355233 @default.
• W2804154027 hasConcept C71924100 @default.
• W2804154027 hasConcept C86803240 @default.
• W2804154027 hasConceptScore W2804154027C10205521 @default.
• W2804154027 hasConceptScore W2804154027C121608353 @default.
• W2804154027 hasConceptScore W2804154027C126322002 @default.
• W2804154027 hasConceptScore W2804154027C142724271 @default.
• W2804154027 hasConceptScore W2804154027C150903083 @default.
• W2804154027 hasConceptScore W2804154027C151872237 @default.
• W2804154027 hasConceptScore W2804154027C18903297 @default.
• W2804154027 hasConceptScore W2804154027C198826908 @default.
• W2804154027 hasConceptScore W2804154027C204232928 @default.
• W2804154027 hasConceptScore W2804154027C207001950 @default.
• W2804154027 hasConceptScore W2804154027C26291073 @default.
• W2804154027 hasConceptScore W2804154027C2776231280 @default.
• W2804154027 hasConceptScore W2804154027C2778019345 @default.
• W2804154027 hasConceptScore W2804154027C2778695046 @default.
• W2804154027 hasConceptScore W2804154027C28328180 @default.
• W2804154027 hasConceptScore W2804154027C502942594 @default.
• W2804154027 hasConceptScore W2804154027C54355233 @default.
• W2804154027 hasConceptScore W2804154027C71924100 @default.
• W2804154027 hasConceptScore W2804154027C86803240 @default.
• W2804154027 hasIssue "6" @default.
• W2804154027 hasLocation W28041540271 @default.
• W2804154027 hasOpenAccess W2804154027 @default.
• W2804154027 hasPrimaryLocation W28041540271 @default.
• W2804154027 hasRelatedWork W2013049481 @default.
• W2804154027 hasRelatedWork W2030334275 @default.
• W2804154027 hasRelatedWork W2353665237 @default.
• W2804154027 hasRelatedWork W2502839568 @default.

• next