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- W2804154151 abstract "Sulfamethoxazole, smz, is an antibiotic that is classified as a Biopharmaceutics Classification System (BCS) class IV, low solubility and low permeability drug. Cocrystal formation has been examined in an attempt to improve solubility. Both ball milling and crystallization from solution have been examined. Ball milling showed that 13 coformers gave new crystalline X-ray powder patterns, and four gave X-ray amorphous patterns, while crystallization from solution gave single crystals of four cocrystals and a salt. The coformers that gave the cocrystals and the salt have better H-bond acceptors than the sulfonyl oxygens of smz. The 4,4-dipyridyl cocrystal has an interesting high Z′′ structure. It crystallized in space group P1 with four smz and six 4,4′-dipyridyl molecules in the asymmetric unit. The highest dissolution rate among the smz cocrystal and co-amorphous systems was shown by the 1,3-di(4-pyridyl)propane cocrystal." @default.
- W2804154151 created "2018-06-01" @default.
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- W2804154151 date "2018-05-23" @default.
- W2804154151 modified "2023-09-30" @default.
- W2804154151 title "Cocrystal Forms of the BCS Class IV Drug Sulfamethoxazole" @default.
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- W2804154151 doi "https://doi.org/10.1021/acs.cgd.8b00216" @default.
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