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- W2804158097 abstract "We designed and synthesized a highly water-soluble biological nanoprobe ([email protected]β-CD) through the covalent bonding of β–cyclodextrin (β-CD) onto the surface of gold nanoclusters (NCs) (Au-GS). The morphology, composition and photophysical properties of as-prepared Au-GS and [email protected]β-CD NCs were fully characterized. The maximum emission intensity at about 600 nm of [email protected]β-CD NCs increased significantly as compared to Au-GS NCs, which is consistent with its effective absorption enhancement. The water solubility and biocompatibility of resultant [email protected]β-CD NCs were also notably enhanced, which allow it to be selectively uptaken by gastric cancer cells (MGC-803) and exhibit red luminescence in the cells. Thus, the as-prepared [email protected]β-CD NCs could be used as promising biological nanoprobes for diagnosis of gastric cancer cells. The successful loading of doxorubicin (DOX) also allows it to hold attractive ability of drug delivery. Moreover, both Au-GS and [email protected]β-CD NCs are thermally responsive. Furthermore, the metal ions detection experiments indicate that both Au-GS NCs and [email protected]β-CD NCs can selectively recognize Pb2+, Al3+, Cu2+, Fe3+ and Ag+ ions through luminescence change. The detection limits of Pb2+ and Fe3+ are improved for [email protected]β-CD NCs due to the synergistic effect of β-CD and Au NCs." @default.
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- W2804158097 date "2018-10-01" @default.
- W2804158097 modified "2023-10-11" @default.
- W2804158097 title "Achieving highly water-soluble and luminescent gold nanoclusters modified by β–cyclodextrin as multifunctional nanoprobe for biological applications" @default.
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- W2804158097 doi "https://doi.org/10.1016/j.dyepig.2018.05.015" @default.
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