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- W2804159563 endingPage "446" @default.
- W2804159563 startingPage "425" @default.
- W2804159563 abstract "RNA polymerases I and II (Pol I and Pol II) are the eukaryotic enzymes that catalyze DNA-dependent synthesis of ribosomal RNA and messenger RNA, respectively. Recent work shows that the transcribing forms of both enzymes are similar and the fundamental mechanisms of RNA chain elongation are conserved. However, the mechanisms of transcription initiation and its regulation differ between Pol I and Pol II. Recent structural studies of Pol I complexes with transcription initiation factors provided insights into how the polymerase recognizes its specific promoter DNA, how it may open DNA, and how initiation may be regulated. Comparison with the well-studied Pol II initiation system reveals a distinct architecture of the initiation complex and visualizes promoter- and gene-class-specific aspects of transcription initiation. On the basis of new structural studies, we derive a model of the Pol I transcription cycle and provide a molecular movie of Pol I transcription that can be used for teaching." @default.
- W2804159563 created "2018-06-01" @default.
- W2804159563 creator A5005665024 @default.
- W2804159563 creator A5008281609 @default.
- W2804159563 creator A5009982309 @default.
- W2804159563 date "2018-05-20" @default.
- W2804159563 modified "2023-09-27" @default.
- W2804159563 title "Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II" @default.
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