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- W2804170710 endingPage "1904" @default.
- W2804170710 startingPage "1896" @default.
- W2804170710 abstract "Oral cavity cancer is a type of head and neck squamous cell carcinoma (HNSCC) and contributes to significant morbidity and mortality each year. An epigenetic pathway of transcriptional inactivation for many genes has been described in various cancers, including HNSCC. For our study, we selected genes for which silencing caused by hypermethylation can promote cancer development. In 75 primary HNSCC tumours and paired surgical margins, we investigated the methylation status of the p16, APC, MGMT, TIMP3 and CDH1 gene promoters by methylation-specific PCR after bisulphite treatment. The promoter methylation rates of p16, APC, MGMT, TIMP3 and CDH1 in tumours were 58.67%, 49.33%, 58.67%, 50.67%, and 57.33% and 50.67%, 41.33%, 37.33%, 42.67%, and 25.33% in the surgical margin, respectively. Our observations confirm the presence of epigenetic changes not only in the cancer cells, but also in the surrounding mucosa and represent a basis for further analysis to unravel these complicated issues. Appropriate cancer risk assessment based on epigenetic alterations in surgical margins may influence a patient's diagnosis and cure." @default.
- W2804170710 created "2018-06-01" @default.
- W2804170710 creator A5001089732 @default.
- W2804170710 creator A5033568796 @default.
- W2804170710 creator A5086130555 @default.
- W2804170710 date "2018-01-01" @default.
- W2804170710 modified "2023-10-16" @default.
- W2804170710 title "Aberrant DNA methylation of the <i>p16, APC, MGMT, TIMP3</i> and<i> CDH1</i> gene promoters in tumours and the surgical margins of patients with oral cavity cancer" @default.
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- W2804170710 doi "https://doi.org/10.7150/jca.24477" @default.