Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804180627> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2804180627 endingPage "106" @default.
- W2804180627 startingPage "100" @default.
- W2804180627 abstract "Ilomastat is a matrix metalloproteinase inhibitor (MMPi) that has shown the potential to inhibit scarring (fibrosis) by mediating healing after injury or surgery. A long lasting ocular implantable pharmaceutical formulation of ilomastat is being developed to mediate the healing process to prevent scarring after glaucoma filtration surgery. The ilomastat implant was coated with water permeable and biocompatible phosphoryl choline polymer (PC1059) displayed extended slow release of ilomastat in vitro and in vivo. The ocular distribution of ilomastat from the implant in rabbits at day 30 post surgery was determined by the extraction of ilomastat and its internal standard marimastat from the ocular tissues, plasma, aqueous humour and vitreous fluid followed by capillary-flow liquid chromatography (cap-LC), the column effluent was directed into a triple quadrupole mass spectrometer operating in product scan mode. The lower limits of quantification (LLOQs) were 0.3 pg/μL for ocular fluids and plasma, and 3 pg/mg for ocular tissues. The extraction recoveries were 90-95% for ilomastat and its internal standard from ocular tissues. Ilomastat was found in ocular fluids and tissues at day 30 after surgery. The level of ilomastat was 18 times higher in the aqueous humour than vitreous humour. The concentration ranking of ilomastat in the ocular tissues was sclera > bleb conjunctiva > conjunctiva (rest of the eye) > cornea. Mass spectrometry analysis to confirm the presence of ilomastat in the ocular tissues and fluids at day 30 post-surgery establishes the extended release of ilomastat can be achieved in vivo, which is crucial information for optimisation of the ilomastat coated implant." @default.
- W2804180627 created "2018-06-01" @default.
- W2804180627 creator A5018268486 @default.
- W2804180627 creator A5022355905 @default.
- W2804180627 creator A5060355775 @default.
- W2804180627 creator A5069175872 @default.
- W2804180627 creator A5069419364 @default.
- W2804180627 creator A5076982441 @default.
- W2804180627 creator A5077673179 @default.
- W2804180627 date "2018-08-01" @default.
- W2804180627 modified "2023-09-27" @default.
- W2804180627 title "LC–MS analysis to determine the biodistribution of a polymer coated ilomastat ocular implant" @default.
- W2804180627 cites W1586814698 @default.
- W2804180627 cites W1928515897 @default.
- W2804180627 cites W1968284386 @default.
- W2804180627 cites W1971641820 @default.
- W2804180627 cites W1986739724 @default.
- W2804180627 cites W2007624423 @default.
- W2804180627 cites W2008601975 @default.
- W2804180627 cites W2013761438 @default.
- W2804180627 cites W2015177938 @default.
- W2804180627 cites W2017348165 @default.
- W2804180627 cites W2017676546 @default.
- W2804180627 cites W2030011072 @default.
- W2804180627 cites W2043053496 @default.
- W2804180627 cites W2043629174 @default.
- W2804180627 cites W2047047519 @default.
- W2804180627 cites W2053043355 @default.
- W2804180627 cites W2067231144 @default.
- W2804180627 cites W2070774058 @default.
- W2804180627 cites W2073364334 @default.
- W2804180627 cites W2076118319 @default.
- W2804180627 cites W2079570021 @default.
- W2804180627 cites W2083480196 @default.
- W2804180627 cites W2119040539 @default.
- W2804180627 cites W2171900392 @default.
- W2804180627 cites W2289248545 @default.
- W2804180627 cites W2342086462 @default.
- W2804180627 cites W2342640622 @default.
- W2804180627 cites W4322388198 @default.
- W2804180627 doi "https://doi.org/10.1016/j.jpba.2018.05.017" @default.
- W2804180627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29777984" @default.
- W2804180627 hasPublicationYear "2018" @default.
- W2804180627 type Work @default.
- W2804180627 sameAs 2804180627 @default.
- W2804180627 citedByCount "2" @default.
- W2804180627 countsByYear W28041806272021 @default.
- W2804180627 countsByYear W28041806272023 @default.
- W2804180627 crossrefType "journal-article" @default.
- W2804180627 hasAuthorship W2804180627A5018268486 @default.
- W2804180627 hasAuthorship W2804180627A5022355905 @default.
- W2804180627 hasAuthorship W2804180627A5060355775 @default.
- W2804180627 hasAuthorship W2804180627A5069175872 @default.
- W2804180627 hasAuthorship W2804180627A5069419364 @default.
- W2804180627 hasAuthorship W2804180627A5076982441 @default.
- W2804180627 hasAuthorship W2804180627A5077673179 @default.
- W2804180627 hasBestOaLocation W28041806272 @default.
- W2804180627 hasConcept C118487528 @default.
- W2804180627 hasConcept C185592680 @default.
- W2804180627 hasConcept C2777100477 @default.
- W2804180627 hasConcept C71924100 @default.
- W2804180627 hasConceptScore W2804180627C118487528 @default.
- W2804180627 hasConceptScore W2804180627C185592680 @default.
- W2804180627 hasConceptScore W2804180627C2777100477 @default.
- W2804180627 hasConceptScore W2804180627C71924100 @default.
- W2804180627 hasLocation W28041806271 @default.
- W2804180627 hasLocation W28041806272 @default.
- W2804180627 hasLocation W28041806273 @default.
- W2804180627 hasLocation W28041806274 @default.
- W2804180627 hasLocation W28041806275 @default.
- W2804180627 hasOpenAccess W2804180627 @default.
- W2804180627 hasPrimaryLocation W28041806271 @default.
- W2804180627 hasRelatedWork W2093024194 @default.
- W2804180627 hasRelatedWork W2375014553 @default.
- W2804180627 hasRelatedWork W2375782316 @default.
- W2804180627 hasRelatedWork W2748952813 @default.
- W2804180627 hasRelatedWork W2899084033 @default.
- W2804180627 hasRelatedWork W3028650816 @default.
- W2804180627 hasRelatedWork W3144440816 @default.
- W2804180627 hasRelatedWork W3212926835 @default.
- W2804180627 hasRelatedWork W4281764192 @default.
- W2804180627 hasRelatedWork W4378977707 @default.
- W2804180627 hasVolume "157" @default.
- W2804180627 isParatext "false" @default.
- W2804180627 isRetracted "false" @default.
- W2804180627 magId "2804180627" @default.
- W2804180627 workType "article" @default.