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- W2804183609 abstract "Tumors cells reprogram their metabolism to fuel rapid growth. The ability to trace nutrient fluxes in the context of specific alterations has provided new mechanistic insight into the process of oncogenic transformation. A broad array of complementary genetic, epigenetic, transcriptional and translational mechanisms has been identified, revealing a metabolic landscape of cancer. However, cancer metabolism is not a static or uniform process, including within a single tumor. Tumor cells adapt to changing environmental conditions, profoundly shaping the enzymatic dependencies of individual cells. The underlying molecular mechanisms of adaptation, and the specific interactions between tumor genotype, oncogenic signaling, and tissue/biochemical context, remain incompletely understood. In this review, we examine dynamic aspects of how metabolic dependencies develop in cancer, shaped both by genotype and biochemical environment, and review how these interlaced processes generate targetable metabolic vulnerabilities. This article is part of a Special Issue entitled: Cancer Metabolism edited by Dr. Chi Van Dang." @default.
- W2804183609 created "2018-06-01" @default.
- W2804183609 creator A5003629072 @default.
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- W2804183609 date "2018-08-01" @default.
- W2804183609 modified "2023-10-12" @default.
- W2804183609 title "Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context" @default.
- W2804183609 cites W1544424898 @default.
- W2804183609 cites W1553978925 @default.
- W2804183609 cites W1567478874 @default.
- W2804183609 cites W1817033456 @default.
- W2804183609 cites W1929533080 @default.
- W2804183609 cites W1932780354 @default.
- W2804183609 cites W1951559178 @default.
- W2804183609 cites W1957365227 @default.
- W2804183609 cites W1957839953 @default.
- W2804183609 cites W1963558982 @default.
- W2804183609 cites W1963933860 @default.
- W2804183609 cites W1965766554 @default.
- W2804183609 cites W1967291345 @default.
- W2804183609 cites W1970527559 @default.
- W2804183609 cites W1972254548 @default.
- W2804183609 cites W1972535033 @default.
- W2804183609 cites W1979521298 @default.
- W2804183609 cites W1980181091 @default.
- W2804183609 cites W1982219839 @default.
- W2804183609 cites W1982789056 @default.
- W2804183609 cites W1987681742 @default.
- W2804183609 cites W1987798277 @default.
- W2804183609 cites W1991510903 @default.
- W2804183609 cites W1992524428 @default.
- W2804183609 cites W1995004586 @default.
- W2804183609 cites W1998284209 @default.
- W2804183609 cites W2003742510 @default.
- W2804183609 cites W2003878114 @default.
- W2804183609 cites W2006842959 @default.
- W2804183609 cites W2010076661 @default.
- W2804183609 cites W2010077871 @default.
- W2804183609 cites W2011400718 @default.
- W2804183609 cites W2011540184 @default.
- W2804183609 cites W2012588998 @default.
- W2804183609 cites W2015202978 @default.
- W2804183609 cites W2016661249 @default.
- W2804183609 cites W2018639404 @default.
- W2804183609 cites W2021536610 @default.
- W2804183609 cites W2030369058 @default.
- W2804183609 cites W2033228549 @default.
- W2804183609 cites W2033278321 @default.
- W2804183609 cites W2034015235 @default.
- W2804183609 cites W2034827327 @default.
- W2804183609 cites W2036659083 @default.
- W2804183609 cites W2040827479 @default.
- W2804183609 cites W2041237929 @default.
- W2804183609 cites W2044433401 @default.
- W2804183609 cites W2044515618 @default.
- W2804183609 cites W2047867594 @default.
- W2804183609 cites W2048255587 @default.
- W2804183609 cites W2051181260 @default.
- W2804183609 cites W2057199368 @default.
- W2804183609 cites W2057650061 @default.
- W2804183609 cites W2058218780 @default.
- W2804183609 cites W2059600528 @default.
- W2804183609 cites W2059747280 @default.
- W2804183609 cites W2060799932 @default.
- W2804183609 cites W2063699306 @default.
- W2804183609 cites W2064318855 @default.
- W2804183609 cites W2064437293 @default.
- W2804183609 cites W2074873270 @default.
- W2804183609 cites W2075023076 @default.
- W2804183609 cites W2077058200 @default.
- W2804183609 cites W2080100938 @default.
- W2804183609 cites W2081826708 @default.
- W2804183609 cites W2082594247 @default.
- W2804183609 cites W2094851085 @default.
- W2804183609 cites W2099711117 @default.
- W2804183609 cites W2100801124 @default.
- W2804183609 cites W2102322990 @default.
- W2804183609 cites W2104450983 @default.
- W2804183609 cites W2108195113 @default.
- W2804183609 cites W2114031931 @default.
- W2804183609 cites W2117293961 @default.
- W2804183609 cites W2119239003 @default.
- W2804183609 cites W2126511952 @default.
- W2804183609 cites W2129185045 @default.
- W2804183609 cites W2129660563 @default.
- W2804183609 cites W2129917557 @default.
- W2804183609 cites W2140814324 @default.
- W2804183609 cites W2141732292 @default.
- W2804183609 cites W2142898716 @default.
- W2804183609 cites W2143394009 @default.
- W2804183609 cites W2144575277 @default.
- W2804183609 cites W2147785354 @default.
- W2804183609 cites W2152319713 @default.
- W2804183609 cites W2152395959 @default.
- W2804183609 cites W2154677603 @default.
- W2804183609 cites W2158107632 @default.