Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804197652> ?p ?o ?g. }
- W2804197652 endingPage "175" @default.
- W2804197652 startingPage "166" @default.
- W2804197652 abstract "Zebrafish hearts can regenerate through activation of growth factors and trans-differentiation of fibroblasts, epicardial, myocardial and endocardial cells, all positive for GATA4 during the process. A possible model of regeneration of the whole heart and the regenerating cells in ex-vivo culture is presented here by a stimulation of cocktail of growth factors. In ex-vivo growth-factors-supplemented culture the heart regeneration was quite complete without signs of fibrosis. Epicardial- and endocardial-derived cells have been analyzed by electron microscopy evidencing two main types: 1) larger/prismatic and 2) small/rounded. Type (1) showed on the surface protein-sculptures, while type(2) was smooth with sparse globular proteins. To confirm their nature we have contemporarily analyzed their proliferative capability and markers-positivity. The cells treated by growth factors have at least two-fold more proliferation with GATA4-positivity. The type (1) cell evidenced WT1+(marker of embryonic epicardium); the type (2) showed NFTA2+(marker of embryonic endocardium); whereas cTNT-cardiotroponin was negative. Under growth factors stimulation, GATA4+/WT1+ and GATA4+/NFTA2+ could be suitable candidates to be the cells with capability to move in/out of the tissue, probably by using their integrins, and it opens the possibility to have long term selected culture to future characterization." @default.
- W2804197652 created "2018-06-01" @default.
- W2804197652 creator A5083437438 @default.
- W2804197652 creator A5084533921 @default.
- W2804197652 date "2018-08-01" @default.
- W2804197652 modified "2023-10-17" @default.
- W2804197652 title "The face of epicardial and endocardial derived cells in zebrafish" @default.
- W2804197652 cites W1598852815 @default.
- W2804197652 cites W1718193936 @default.
- W2804197652 cites W1836410971 @default.
- W2804197652 cites W1966202908 @default.
- W2804197652 cites W1984514695 @default.
- W2804197652 cites W1993932646 @default.
- W2804197652 cites W1997529197 @default.
- W2804197652 cites W1998457769 @default.
- W2804197652 cites W2000159717 @default.
- W2804197652 cites W2007631412 @default.
- W2804197652 cites W2021554725 @default.
- W2804197652 cites W2021826108 @default.
- W2804197652 cites W2028036560 @default.
- W2804197652 cites W2034862301 @default.
- W2804197652 cites W2035005072 @default.
- W2804197652 cites W2038850974 @default.
- W2804197652 cites W2041265425 @default.
- W2804197652 cites W2042090952 @default.
- W2804197652 cites W2050131895 @default.
- W2804197652 cites W2066287407 @default.
- W2804197652 cites W2072375631 @default.
- W2804197652 cites W2075344844 @default.
- W2804197652 cites W2080539468 @default.
- W2804197652 cites W2102638266 @default.
- W2804197652 cites W2106111979 @default.
- W2804197652 cites W2122059700 @default.
- W2804197652 cites W2122349854 @default.
- W2804197652 cites W2126747203 @default.
- W2804197652 cites W2142635755 @default.
- W2804197652 cites W2148220540 @default.
- W2804197652 cites W2149161770 @default.
- W2804197652 cites W2329542418 @default.
- W2804197652 cites W2408316087 @default.
- W2804197652 cites W2596186147 @default.
- W2804197652 cites W2614186512 @default.
- W2804197652 cites W2623156160 @default.
- W2804197652 cites W2794991451 @default.
- W2804197652 cites W2806030431 @default.
- W2804197652 cites W2807629014 @default.
- W2804197652 cites W4211016865 @default.
- W2804197652 doi "https://doi.org/10.1016/j.yexcr.2018.05.022" @default.
- W2804197652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29807022" @default.
- W2804197652 hasPublicationYear "2018" @default.
- W2804197652 type Work @default.
- W2804197652 sameAs 2804197652 @default.
- W2804197652 citedByCount "6" @default.
- W2804197652 countsByYear W28041976522019 @default.
- W2804197652 countsByYear W28041976522020 @default.
- W2804197652 countsByYear W28041976522021 @default.
- W2804197652 countsByYear W28041976522022 @default.
- W2804197652 crossrefType "journal-article" @default.
- W2804197652 hasAuthorship W2804197652A5083437438 @default.
- W2804197652 hasAuthorship W2804197652A5084533921 @default.
- W2804197652 hasConcept C104317684 @default.
- W2804197652 hasConcept C105702510 @default.
- W2804197652 hasConcept C116186050 @default.
- W2804197652 hasConcept C126322002 @default.
- W2804197652 hasConcept C145103041 @default.
- W2804197652 hasConcept C1491633281 @default.
- W2804197652 hasConcept C150194340 @default.
- W2804197652 hasConcept C171056886 @default.
- W2804197652 hasConcept C195687474 @default.
- W2804197652 hasConcept C207001950 @default.
- W2804197652 hasConcept C26291073 @default.
- W2804197652 hasConcept C2776878037 @default.
- W2804197652 hasConcept C54355233 @default.
- W2804197652 hasConcept C71924100 @default.
- W2804197652 hasConcept C85378888 @default.
- W2804197652 hasConcept C86803240 @default.
- W2804197652 hasConcept C95444343 @default.
- W2804197652 hasConceptScore W2804197652C104317684 @default.
- W2804197652 hasConceptScore W2804197652C105702510 @default.
- W2804197652 hasConceptScore W2804197652C116186050 @default.
- W2804197652 hasConceptScore W2804197652C126322002 @default.
- W2804197652 hasConceptScore W2804197652C145103041 @default.
- W2804197652 hasConceptScore W2804197652C1491633281 @default.
- W2804197652 hasConceptScore W2804197652C150194340 @default.
- W2804197652 hasConceptScore W2804197652C171056886 @default.
- W2804197652 hasConceptScore W2804197652C195687474 @default.
- W2804197652 hasConceptScore W2804197652C207001950 @default.
- W2804197652 hasConceptScore W2804197652C26291073 @default.
- W2804197652 hasConceptScore W2804197652C2776878037 @default.
- W2804197652 hasConceptScore W2804197652C54355233 @default.
- W2804197652 hasConceptScore W2804197652C71924100 @default.
- W2804197652 hasConceptScore W2804197652C85378888 @default.
- W2804197652 hasConceptScore W2804197652C86803240 @default.
- W2804197652 hasConceptScore W2804197652C95444343 @default.
- W2804197652 hasIssue "1" @default.
- W2804197652 hasLocation W28041976521 @default.
- W2804197652 hasLocation W28041976522 @default.
- W2804197652 hasOpenAccess W2804197652 @default.