FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804201737> ?p ?o ?g. }

• W2804201737 abstract "The aim of the present study was to investigate the key pathways and genes in the progression of cervical cancer. The gene expression profiles GSE7803 and GSE63514 were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified using GEO2R and the limma package, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted using the Database for Annotation, Visualization and Integrated Discovery. The hub genes were identified using Cytoscape and protein-protein interaction (PPI) networks were constructed using the STRING database. A total of 127 and 99 DEGs were identified in the pre-invasive and invasive stages of cervical cancer, respectively. GO enrichment analysis indicated that the DEGs in pre-invasive cervical cancer were primarily associated with the 'protein binding', 'single-stranded DNA-dependent ATPase activity', 'DNA replication origin binding' and 'microtubule binding' terms, whereas the DEGs in invasive cervical cancer were associated with the 'extracellular matrix (ECM) structural constituent', 'heparin binding' and 'integrin binding'. KEGG enrichment analysis revealed that the pre-invasive DEGs were significantly enriched in the 'cell cycle', 'DNA replication' and 'p53 signaling pathway' terms, while the invasive DEGs were enriched in the 'amoebiasis', 'focal adhesion', 'ECM-receptor interaction' and 'platelet activation' terms. The PPI network identified 4 key genes (PCNA, CDK2, VEGFA and PIK3CA), which were hub genes for pre-invasive and invasive cervical cancer. In conclusion, bioinformatics analysis identified 4 key genes in cervical cancer progression (PCNA, CDK2, VEGFA and PIK3CA), which may be potential biomarkers for differentiating normal cervical epithelial tissue from cervical cancer." @default.
• W2804201737 created "2018-06-01" @default.
• W2804201737 creator A5014330055 @default.
• W2804201737 creator A5052987782 @default.
• W2804201737 creator A5053518577 @default.
• W2804201737 creator A5056423974 @default.
• W2804201737 creator A5059822057 @default.
• W2804201737 creator A5079533477 @default.
• W2804201737 date "2018-05-22" @default.
• W2804201737 modified "2023-09-30" @default.
• W2804201737 title "Identification of key pathways and genes in the progression of cervical cancer using bioinformatics analysis" @default.
• W2804201737 cites W1968170113 @default.
• W2804201737 cites W1971298466 @default.
• W2804201737 cites W1988124776 @default.
• W2804201737 cites W1994151970 @default.
• W2804201737 cites W1994480447 @default.
• W2804201737 cites W1997220554 @default.
• W2804201737 cites W2009679624 @default.
• W2804201737 cites W2011912935 @default.
• W2804201737 cites W2014007705 @default.
• W2804201737 cites W2017777108 @default.
• W2804201737 cites W2036216046 @default.
• W2804201737 cites W2039174864 @default.
• W2804201737 cites W2066925516 @default.
• W2804201737 cites W2073847055 @default.
• W2804201737 cites W2089080407 @default.
• W2804201737 cites W2101688706 @default.
• W2804201737 cites W2102777569 @default.
• W2804201737 cites W2103912979 @default.
• W2804201737 cites W2109406858 @default.
• W2804201737 cites W2123820544 @default.
• W2804201737 cites W2124890939 @default.
• W2804201737 cites W2150782426 @default.
• W2804201737 cites W2159482845 @default.
• W2804201737 cites W2159675211 @default.
• W2804201737 cites W2171854972 @default.
• W2804201737 cites W2312633322 @default.
• W2804201737 cites W2334955491 @default.
• W2804201737 cites W2428590888 @default.
• W2804201737 cites W2585581952 @default.
• W2804201737 cites W2618180831 @default.
• W2804201737 cites W2917837889 @default.
• W2804201737 cites W3021382792 @default.
• W2804201737 cites W4231824804 @default.
• W2804201737 cites W4294216483 @default.
• W2804201737 cites W2041509523 @default.
• W2804201737 doi "https://doi.org/10.3892/ol.2018.8768" @default.
• W2804201737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6019941" @default.
• W2804201737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29963176" @default.
• W2804201737 hasPublicationYear "2018" @default.
• W2804201737 type Work @default.
• W2804201737 sameAs 2804201737 @default.
• W2804201737 citedByCount "15" @default.
• W2804201737 countsByYear W28042017372019 @default.
• W2804201737 countsByYear W28042017372020 @default.
• W2804201737 countsByYear W28042017372021 @default.
• W2804201737 countsByYear W28042017372022 @default.
• W2804201737 countsByYear W28042017372023 @default.
• W2804201737 crossrefType "journal-article" @default.
• W2804201737 hasAuthorship W2804201737A5014330055 @default.
• W2804201737 hasAuthorship W2804201737A5052987782 @default.
• W2804201737 hasAuthorship W2804201737A5053518577 @default.
• W2804201737 hasAuthorship W2804201737A5056423974 @default.
• W2804201737 hasAuthorship W2804201737A5059822057 @default.
• W2804201737 hasAuthorship W2804201737A5079533477 @default.
• W2804201737 hasBestOaLocation W28042017371 @default.
• W2804201737 hasConcept C104317684 @default.
• W2804201737 hasConcept C150194340 @default.
• W2804201737 hasConcept C152724338 @default.
• W2804201737 hasConcept C162317418 @default.
• W2804201737 hasConcept C2781018059 @default.
• W2804201737 hasConcept C29537977 @default.
• W2804201737 hasConcept C54355233 @default.
• W2804201737 hasConcept C70721500 @default.
• W2804201737 hasConcept C86803240 @default.
• W2804201737 hasConceptScore W2804201737C104317684 @default.
• W2804201737 hasConceptScore W2804201737C150194340 @default.
• W2804201737 hasConceptScore W2804201737C152724338 @default.
• W2804201737 hasConceptScore W2804201737C162317418 @default.
• W2804201737 hasConceptScore W2804201737C2781018059 @default.
• W2804201737 hasConceptScore W2804201737C29537977 @default.
• W2804201737 hasConceptScore W2804201737C54355233 @default.
• W2804201737 hasConceptScore W2804201737C70721500 @default.
• W2804201737 hasConceptScore W2804201737C86803240 @default.
• W2804201737 hasLocation W28042017371 @default.
• W2804201737 hasLocation W28042017372 @default.
• W2804201737 hasLocation W28042017373 @default.
• W2804201737 hasLocation W28042017374 @default.
• W2804201737 hasOpenAccess W2804201737 @default.
• W2804201737 hasPrimaryLocation W28042017371 @default.
• W2804201737 hasRelatedWork W2021865867 @default.
• W2804201737 hasRelatedWork W2568799188 @default.
• W2804201737 hasRelatedWork W2765689886 @default.
• W2804201737 hasRelatedWork W2766648346 @default.
• W2804201737 hasRelatedWork W2802217527 @default.
• W2804201737 hasRelatedWork W2805873130 @default.
• W2804201737 hasRelatedWork W2888263538 @default.
• W2804201737 hasRelatedWork W2909382709 @default.
• W2804201737 hasRelatedWork W2999397373 @default.
• W2804201737 hasRelatedWork W3134676575 @default.

• next