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• W2804244016 abstract "Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar genomic regions and the Flag-H1.0 binding was not changed upon MeCP2 depletion. Furthermore, mild overexpression of H1.0 did not alter MeCP2 binding, suggesting that the functional binding of MeCP2 and H1.0 are largely independent." @default.
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• W2804244016 date "2018-05-25" @default.
• W2804244016 modified "2023-09-26" @default.
• W2804244016 title "Genome-wide distribution of linker histone H1.0 is independent of MeCP2" @default.
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• W2804244016 doi "https://doi.org/10.1038/s41593-018-0155-8" @default.
• W2804244016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6099063" @default.
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