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- W2804245268 abstract "We aimed to analyze the relationship between the combination with hypertension and the level of inflammatory cytokines in peripheral serum in patients with type 2 diabetes mellitus (DM), and to explore the value of inflammatory cytokines in predicting type 2 DM combined with hypertension.A total of 120 patients diagnosed with type 2 DM in our hospital from March 2014 to September 2016 were selected. The clinical data were retrospectively analyzed. These patients were divided into the combination with hypertension group (N.=56) and the non-combination with hypertension group (N.=64), including 75 males and 45 females.Duration of DM, fasting plasma glucose (FPG), glycosylated hemoglobin A1c (HbA1c) and also levels of inflammatory cytokines (hs-CRP, TNF-α and IL-6) in the combination with hypertension group were all significantly higher than those in the non-combination with hypertension group (P<0.05). The incidence rate of hypertension in patients with high-level hs-CRP, high-level TNF-α and high-level IL-6 were significantly higher than that in patients with normal levels (P<0.05). Type 2 DM patients with high-level inflammatory cytokines had significantly longer duration of DM, and higher FPG and HbA1c values than those with normal levels (P<0.05). Results also showed that hs-CRP, TNF-α and IL-6 were positively correlated with FPG, HbA1c and the hypertension grade, and FPG and HbA1c were also positively correlated with the hypertension grade.Logistic regression analysis revealed that hs-CRP, TNF-α, IL-6, the duration of DM, BMI, FPG, HbA1c, TC and LDL had independent values in predicting Type 2 DM combined with hypertension (P<0.05).Levels of serum hs-CRP, TNF-α and IL-6 are significantly elevated in patients with type 2 DM combined with essential hypertension, which are important factors affecting changes in blood glucose. The higher the level of inflammatory cytokines is, the higher the grade of hypertension will be." @default.
- W2804245268 created "2018-06-01" @default.
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- W2804245268 date "2019-07-01" @default.
- W2804245268 modified "2023-10-16" @default.
- W2804245268 title "Correlation between changes in inflammatory cytokines and the combination with hypertension in patients with type 2 diabetes mellitus" @default.
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- W2804245268 doi "https://doi.org/10.23736/s0391-1977.18.02822-5" @default.
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