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• W2804287495 abstract "Summary Background Previous review from randomized controlled trials (RCT) showed that patients with cryptogenic stroke may benefit from patent foramen ovale ( PFO ) closure. However, the findings from the systematic review were not clear when observational studies were also included. Methods We searched MEDLINE , Embase, and Cochrane databases. The primary endpoints were recurrent stroke or transient ischemic attack ( TIA ). The secondary outcomes were all‐cause death, atrial fibrillation ( AF ), and hemorrhagic events. Results Five randomized trials and fourteen observational studies (6301 participants) were eligible. PFO closure was superior to medical therapy for stroke prevention risk ratios ([ RR ], 0.38; 95% CI , 0.24‐0.60), but showed increased risk of AF ( RR , 4.96; 95% CI , 2.31‐10.7). There was no significant difference in TIA recurrence, death, and hemorrhagic events. Subgroup analyses showed that patients with factors such as substantial residual shunt, the presence of atrial septal aneurysm ( ASA ), male, and age <45 years had a lower risk of recurrent stroke when PFO s were closed. Conclusions In patients with cryptogenic stroke, PFO closure does appeared to be superior to medical therapy in stroke prevention, with an increased incidence of AF . Male, age <45 years, substantial residual shunt, and the history of ASA are the factors that will predict the benefit when PFO is closed." @default.
• W2804287495 created "2018-06-01" @default.
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• W2804287495 date "2018-05-27" @default.
• W2804287495 modified "2023-10-06" @default.
• W2804287495 title "Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies" @default.
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• W2804287495 doi "https://doi.org/10.1111/cns.12980" @default.
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