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- W2804291736 abstract "Abstract Objective To determine the prevalence of HLA-B*5701 allele in HIV-infected children, and to find its association with Abacavir hypersensitivity. Methods Children (2 to 18 y) already on, or to be initiated on Abacavir were included for PCR sequencing to detect HLA-B*5701. Outcome measures were: proportion with HLA B*5701 allele and hypersensitivity with Abacavir. Abacavir was stopped if patient tested positive for HLA-B*5701 allele. Results 100 children (median age 11 y) were enrolled; 10 were already on Abacavir. HLA-B*5701 positivity was observed in 11 (11%) children. Two of these 11 children developed hypersensitivity after initiation of Abacavir. Abacavir was thereafter stopped in all who tested HLA-B*5701 positive, irrespective of the development of hypersensitivity reaction. Conclusions HLA-B*5701 allele was present in 11 (11%) of HIV-infected children, of which two developed Abacavir hypersensitivity. None of the patients without the allele developed hypersensitivity." @default.
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- W2804291736 date "2017-12-14" @default.
- W2804291736 modified "2023-09-27" @default.
- W2804291736 title "HLA-B*5701 Allele in HIV-infected Indian Children and its Association with Abacavir Hypersensitivity" @default.
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- W2804291736 doi "https://doi.org/10.1007/s13312-018-1248-x" @default.
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