FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804295521> ?p ?o ?g. }

• W2804295521 endingPage "9" @default.
• W2804295521 startingPage "1" @default.
• W2804295521 abstract "Desynchronization of circadian rhythms is a hallmark of depression. The antidepressant agomelatine, which is an MT1/MT2 melatonin receptor agonist/5-HT2C serotonin receptor antagonist has advantages compared to the selective serotonin reuptake inhibitors as a circadian phase-shifting agent. The present study was designed to explore whether agomelatine is able to have an antidepressant effect on rats exposed to chronic constant light (CCL) for 6 weeks. Focus is also placed on whether this activity affects diurnal rhythms of depressive-like symptoms and is associated with restoration of impaired circadian rhythms in plasma melatonin and corticosterone. We report that CCL induced a depressive-like symptoms associated with decreased grooming in the splash test during the subjective light/inactive phase. Anhedonia-like deficit in the saccharine preference test and increased immobility in the forced swimming test were both detected during the subjective dark/active phase. The disturbed emotional fluctuations due to CCL were corrected by agomelatine treatment (40 mg/kg, i.p. for 3 weeks). Agomelatine also restored novelty-induced hypophagia, which reflects an anxiety state, during the subjective Light and Dark phase, respectively, in rats exposed to CCL. Parallel to the observed positive influence on behavior, this melatonin analogue restored impaired circadian patterns of plasma melatonin but not that of corticosterone. These findings demonstrated the antidepressant-like effect of agomelatine in rats exposed to CCL possibly exerted via correction of melatonin rhythms and are suggestive of the therapeutic potential of this drug in a subpopulation of people characterized by a melatonin deficit." @default.
• W2804295521 created "2018-06-01" @default.
• W2804295521 creator A5013855566 @default.
• W2804295521 creator A5023045650 @default.
• W2804295521 creator A5029631914 @default.
• W2804295521 creator A5054977145 @default.
• W2804295521 creator A5061718181 @default.
• W2804295521 date "2018-08-01" @default.
• W2804295521 modified "2023-10-16" @default.
• W2804295521 title "Agomelatine treatment corrects symptoms of depression and anxiety by restoring the disrupted melatonin circadian rhythms of rats exposed to chronic constant light" @default.
• W2804295521 cites W1529328461 @default.
• W2804295521 cites W1931341966 @default.
• W2804295521 cites W1965027767 @default.
• W2804295521 cites W1965355495 @default.
• W2804295521 cites W1966246322 @default.
• W2804295521 cites W1967191643 @default.
• W2804295521 cites W1967424611 @default.
• W2804295521 cites W1969112537 @default.
• W2804295521 cites W1972803640 @default.
• W2804295521 cites W1973950070 @default.
• W2804295521 cites W1984884973 @default.
• W2804295521 cites W1985541217 @default.
• W2804295521 cites W1986419052 @default.
• W2804295521 cites W1990568149 @default.
• W2804295521 cites W1990846263 @default.
• W2804295521 cites W1998011441 @default.
• W2804295521 cites W1998894503 @default.
• W2804295521 cites W1999807139 @default.
• W2804295521 cites W2002206403 @default.
• W2804295521 cites W2002624310 @default.
• W2804295521 cites W2003545653 @default.
• W2804295521 cites W2005417962 @default.
• W2804295521 cites W2009302246 @default.
• W2804295521 cites W2009823500 @default.
• W2804295521 cites W2013987967 @default.
• W2804295521 cites W2015683660 @default.
• W2804295521 cites W2016556735 @default.
• W2804295521 cites W2018707355 @default.
• W2804295521 cites W2022083293 @default.
• W2804295521 cites W2025224792 @default.
• W2804295521 cites W2028435476 @default.
• W2804295521 cites W2033265487 @default.
• W2804295521 cites W2038826847 @default.
• W2804295521 cites W2048106194 @default.
• W2804295521 cites W2052946422 @default.
• W2804295521 cites W2072472304 @default.
• W2804295521 cites W2076326440 @default.
• W2804295521 cites W2077183950 @default.
• W2804295521 cites W2086546977 @default.
• W2804295521 cites W2087371709 @default.
• W2804295521 cites W2089895453 @default.
• W2804295521 cites W2090099613 @default.
• W2804295521 cites W2099864226 @default.
• W2804295521 cites W2104247936 @default.
• W2804295521 cites W2119617632 @default.
• W2804295521 cites W2122069393 @default.
• W2804295521 cites W2130100911 @default.
• W2804295521 cites W2136903508 @default.
• W2804295521 cites W2146383397 @default.
• W2804295521 cites W2146592193 @default.
• W2804295521 cites W2161731199 @default.
• W2804295521 cites W2166636921 @default.
• W2804295521 cites W2233780156 @default.
• W2804295521 cites W2239063774 @default.
• W2804295521 cites W2329166121 @default.
• W2804295521 cites W2510666910 @default.
• W2804295521 cites W2524535806 @default.
• W2804295521 cites W2606177739 @default.
• W2804295521 cites W2932420369 @default.
• W2804295521 doi "https://doi.org/10.1016/j.pbb.2018.05.016" @default.
• W2804295521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29807067" @default.
• W2804295521 hasPublicationYear "2018" @default.
• W2804295521 type Work @default.
• W2804295521 sameAs 2804295521 @default.
• W2804295521 citedByCount "40" @default.
• W2804295521 countsByYear W28042955212018 @default.
• W2804295521 countsByYear W28042955212019 @default.
• W2804295521 countsByYear W28042955212020 @default.
• W2804295521 countsByYear W28042955212021 @default.
• W2804295521 countsByYear W28042955212022 @default.
• W2804295521 countsByYear W28042955212023 @default.
• W2804295521 crossrefType "journal-article" @default.
• W2804295521 hasAuthorship W2804295521A5013855566 @default.
• W2804295521 hasAuthorship W2804295521A5023045650 @default.
• W2804295521 hasAuthorship W2804295521A5029631914 @default.
• W2804295521 hasAuthorship W2804295521A5054977145 @default.
• W2804295521 hasAuthorship W2804295521A5061718181 @default.
• W2804295521 hasConcept C121446783 @default.
• W2804295521 hasConcept C126322002 @default.
• W2804295521 hasConcept C134018914 @default.
• W2804295521 hasConcept C136569192 @default.
• W2804295521 hasConcept C15744967 @default.
• W2804295521 hasConcept C170493617 @default.
• W2804295521 hasConcept C2775864247 @default.
• W2804295521 hasConcept C2778182776 @default.
• W2804295521 hasConcept C2778938600 @default.
• W2804295521 hasConcept C2778941446 @default.
• W2804295521 hasConcept C2779177272 @default.

• next