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• W2804344825 abstract "Aim: The design and synthesis of chromenopyrimidines as microtubule destabilizing agents. Materials & methods: Novel chromenopyrimidines and chromenotriazolopyrimidines were prepared and evaluated for their cytotoxicity against MCF-7 cell line. The most potent compound was tested for its possible effect on tubulin inhibition, cell cycle distribution, apoptosis initiation and caspase-3 activation. Results: All the prepared compounds showed potent cytotoxic activity. Compound 13 was the most prominent (IC 50 = 0.13 μM on tumor cell line MCF-7 and 14.06 μM on mammary epithelial cell line MCF-10A). Compound 13 inhibited tubulin polymerization (IC 50 = 8.39 μM), caused cell cycle arrest at G2/M phase (fivefold more than control) and cellular apoptosis. Compound 13 increased the level of active caspase-3, 12-fold compared with control." @default.
• W2804344825 created "2018-06-01" @default.
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• W2804344825 date "2018-06-01" @default.
• W2804344825 modified "2023-09-27" @default.
• W2804344825 title "Design, synthesis and biological evaluation of chromenopyrimidines as potential cytotoxic agents" @default.
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• W2804344825 doi "https://doi.org/10.4155/fmc-2017-0324" @default.
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