FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804346919> ?p ?o ?g. }

• W2804346919 endingPage "1625" @default.
• W2804346919 startingPage "1617" @default.
• W2804346919 abstract "Folate receptors (FRs) hold great potential as important diagnostic and prognostic biological marker for cancer.To assess the targeted capability of the FR-targeted perfluorocarbon (PFC) nanoparticles and to assess in vivo the relationship between FR expression and tumor proliferation with fluorine-19 (19 F) MR molecular imaging.Prospective animal cancer model.H460 (n = 14) and A549 (n = 14) nude mice subcutaneous tumor models.9.4T, 1 H and 19 F RARE sequences.Intracellular uptake of the PFC nanoparticles was tested in H460 and A549 cell lines. 19 F MRI of H460 and A549 subcutaneous tumors was performed following intravenous injection of PFC nanoparticles. The concentration of PFC in tumors were compared. 3'-Deoxy-3'-18 F-fluorothymidine (18 F-FLT) positron emission tomography / computed tomography (PET/CT) imaging, Ki-67, and proliferating cell nuclear antigen (PCNA) staining were performed to confirm tumor proliferation.One-way or two-way analysis of variance. P < 0.05 was considered a significant difference.The diameter of the FR-targeted nanoparticles was 108.8 ± 0.56 nm, and the zeta potential was -58.4 ± 10.8 mV. H460 cells incubated with FR-targeted nanoparticles showed ∼59.87 ± 3.91% nanoparticles-labeled, which is significantly higher than the other groups (P < 0.001). The PFC concentration in H460 tumors after injection with FR-targeted nanoparticles was 4.64 ± 1.21, 8.04 ± 1.38, and 9.16 ± 2.56 mmol/L at 8 hours, 24 hours, and 48 hours, respectively (P < 0.05 compared to others). The ratio of 18 F-FLT uptake for H460 and A549 tumors was 3.32 ± 0.17 and 1.48 ± 0.09 (P < 0.05), and there was more Ki-67 and PCNA in H460 tumor than A549. DATA CONCLUSION: 19 F MRI with FR-targeted PFC nanoparticles can be used in differentiating of FR-positive and FR-negative tumors, and further, in evaluation of the two cancer models proliferation.1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1617-1625." @default.
• W2804346919 created "2018-06-01" @default.
• W2804346919 creator A5013254367 @default.
• W2804346919 creator A5025202937 @default.
• W2804346919 creator A5034672378 @default.
• W2804346919 creator A5047489767 @default.
• W2804346919 creator A5073531557 @default.
• W2804346919 creator A5074325827 @default.
• W2804346919 creator A5082395470 @default.
• W2804346919 creator A5082831505 @default.
• W2804346919 creator A5087695635 @default.
• W2804346919 creator A5089226050 @default.
• W2804346919 date "2018-05-13" @default.
• W2804346919 modified "2023-10-13" @default.
• W2804346919 title "Folate receptor-targeted ¹⁹ F MR molecular imaging and proliferation evaluation of lung cancer" @default.
• W2804346919 cites W1517245896 @default.
• W2804346919 cites W1933750051 @default.
• W2804346919 cites W1963675633 @default.
• W2804346919 cites W1963776452 @default.
• W2804346919 cites W1963880672 @default.
• W2804346919 cites W1967727706 @default.
• W2804346919 cites W1967863709 @default.
• W2804346919 cites W1968583232 @default.
• W2804346919 cites W1972647884 @default.
• W2804346919 cites W1977871291 @default.
• W2804346919 cites W1980773456 @default.
• W2804346919 cites W1987934775 @default.
• W2804346919 cites W1988669078 @default.
• W2804346919 cites W1989937795 @default.
• W2804346919 cites W2016611536 @default.
• W2804346919 cites W2027977341 @default.
• W2804346919 cites W2039693127 @default.
• W2804346919 cites W2043179683 @default.
• W2804346919 cites W2046635748 @default.
• W2804346919 cites W2064166274 @default.
• W2804346919 cites W2088921280 @default.
• W2804346919 cites W2098241837 @default.
• W2804346919 cites W2103953940 @default.
• W2804346919 cites W2108615682 @default.
• W2804346919 cites W2109621565 @default.
• W2804346919 cites W2123559008 @default.
• W2804346919 cites W2124863256 @default.
• W2804346919 cites W2143809364 @default.
• W2804346919 cites W2145912883 @default.
• W2804346919 cites W2160970049 @default.
• W2804346919 cites W2176671673 @default.
• W2804346919 cites W2214859819 @default.
• W2804346919 cites W2566349223 @default.
• W2804346919 cites W2621990038 @default.
• W2804346919 cites W2737331358 @default.
• W2804346919 cites W2769087605 @default.
• W2804346919 cites W2917837889 @default.
• W2804346919 cites W4293052525 @default.
• W2804346919 doi "https://doi.org/10.1002/jmri.26177" @default.
• W2804346919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29756310" @default.
• W2804346919 hasPublicationYear "2018" @default.
• W2804346919 type Work @default.
• W2804346919 sameAs 2804346919 @default.
• W2804346919 citedByCount "8" @default.
• W2804346919 countsByYear W28043469192019 @default.
• W2804346919 countsByYear W28043469192020 @default.
• W2804346919 countsByYear W28043469192022 @default.
• W2804346919 countsByYear W28043469192023 @default.
• W2804346919 crossrefType "journal-article" @default.
• W2804346919 hasAuthorship W2804346919A5013254367 @default.
• W2804346919 hasAuthorship W2804346919A5025202937 @default.
• W2804346919 hasAuthorship W2804346919A5034672378 @default.
• W2804346919 hasAuthorship W2804346919A5047489767 @default.
• W2804346919 hasAuthorship W2804346919A5073531557 @default.
• W2804346919 hasAuthorship W2804346919A5074325827 @default.
• W2804346919 hasAuthorship W2804346919A5082395470 @default.
• W2804346919 hasAuthorship W2804346919A5082831505 @default.
• W2804346919 hasAuthorship W2804346919A5087695635 @default.
• W2804346919 hasAuthorship W2804346919A5089226050 @default.
• W2804346919 hasConcept C121608353 @default.
• W2804346919 hasConcept C126322002 @default.
• W2804346919 hasConcept C142724271 @default.
• W2804346919 hasConcept C150903083 @default.
• W2804346919 hasConcept C153911025 @default.
• W2804346919 hasConcept C170493617 @default.
• W2804346919 hasConcept C185592680 @default.
• W2804346919 hasConcept C204232928 @default.
• W2804346919 hasConcept C207001950 @default.
• W2804346919 hasConcept C2775842073 @default.
• W2804346919 hasConcept C2776256026 @default.
• W2804346919 hasConcept C2780306303 @default.
• W2804346919 hasConcept C2781230642 @default.
• W2804346919 hasConcept C2989005 @default.
• W2804346919 hasConcept C34688535 @default.
• W2804346919 hasConcept C502942594 @default.
• W2804346919 hasConcept C55493867 @default.
• W2804346919 hasConcept C62112901 @default.
• W2804346919 hasConcept C71924100 @default.
• W2804346919 hasConcept C81729549 @default.
• W2804346919 hasConcept C86803240 @default.
• W2804346919 hasConcept C96232424 @default.
• W2804346919 hasConceptScore W2804346919C121608353 @default.
• W2804346919 hasConceptScore W2804346919C126322002 @default.

• next