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• W2804354477 abstract "Autofluorescence background in complex biological samples is a major challenge in achieving high sensitivity of fluorescence immunoassays (FIA). Here we report an X-ray luminescence-based immunoassay for high-sensitivity detection of biomarkers using X-ray scintillating nanotags. Due to the weak scattering and absorption of most biological chromophores by X-ray excitation, a low-dose X-ray source can be used to produce intense scintillating luminescence from the nanotags for autofluorescence-free biosensing. To demonstrate this concept, we designed and synthesized NaGdF4:Tb@NaYF4 core/shell nanoparticles as kind of high-efficiency X-ray scintillating nanotags, which are able to convert high-energy X-ray photons to visible light without autofluorescence in biological samples. Notably, strong X-ray absorption and minimized surface quenching arising from the heavy Gd3+/Tb3+ atoms and core/shell architecture of the nanoparticles were found to be critically important for high-efficiency X-ray excited luminescence for high-sensitivity biosensing. Our method allows for sensing alpha-fetoprotein (AFP) biomarkers with a detection limit down to 0.25 ng/mL. Moreover, the as-described X-ray luminescence immunoassay exhibited an excellent biological specificity, high stability, and sample recovery, implying an opportunity for applications in complex biological samples. Consequently, our method can be readily extended for multiplexing sensing and medical diagnosis." @default.
• W2804354477 created "2018-06-01" @default.
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• W2804354477 date "2018-05-14" @default.
• W2804354477 modified "2023-10-16" @default.
• W2804354477 title "Autofluorescence-Free Immunoassay Using X-ray Scintillating Nanotags" @default.
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• W2804354477 doi "https://doi.org/10.1021/acs.analchem.8b01315" @default.
• W2804354477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29757612" @default.
• W2804354477 hasPublicationYear "2018" @default.
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