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• W2804374089 abstract "Abstract The CRISPR-Cas9 system provides the ability to edit, repress, activate, or mark any gene (or DNA element) by pairing of a programmable single guide RNA (sgRNA) with a complementary sequence on the DNA target. Here we present a new method for small-molecule control of CRISPR-Cas9 function through insertion of RNA aptamers into the sgRNA. We show that CRISPR-Cas9-based gene repression (CRISPRi) can be either activated or deactivated in a dose-dependent fashion over a >10-fold dynamic range in response to two different small-molecule ligands. Since our system acts directly on each target-specific sgRNA, it enables new applications that require differential and opposing temporal control of multiple genes." @default.
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• W2804374089 date "2018-05-15" @default.
• W2804374089 modified "2023-09-25" @default.
• W2804374089 title "Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs" @default.
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• W2804374089 doi "https://doi.org/10.1101/323105" @default.
• W2804374089 hasPublicationYear "2018" @default.
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