Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804383336> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2804383336 abstract "The aim of this study was to investigate the efficacy and safety of first-line panitumumab plus folinic acid, 5-fluorouracil and irinotecan (FOLFIRI) in patients with wild-type KRAS and wild-type NRAS metastatic colorectal cancer (mCRC). Patients with wild-type KRAS and wild-type NRAS mCRC presenting to the medical oncology department of the Okmeydani Training and Research Hospital in Istanbul, Turkey, between April 2014 and January 2018 were enrolled in this study. A total of 64 patients (35 males and 29 females) with a median age of 59 (35–81) years old were enrolled. The median follow-up was 18.9 months, and the median progression-free survival was 13 months. The median overall survival (OS) was 26 months in the patients with wild-type KRAS and wild-type NRAS mCRC. It was 90.4% for the 6-month OS, 79.5% for the 1-year OS, 53.7% for the 2-year OS and 31.1% for the 3-year OS. The median OS of the patients who underwent metastasectomies was 40 [95% confidence interval (CI) = 19.9–60.1] months, and the median OS of the patients without metastasectomies was 22 (95% CI = 17.7–26.4) months. There was a statistically significant difference between these (P = 0.007). The first-line FOLFIRI plus panitumumab was associated with favourable efficacy in the patients with wild-type KRAS and wild-type NRAS mCRC, and it was well tolerated. The removal of the metastases that became resectable after chemotherapy further prolonged the patients’ survival. Retrospectively registered: 33886" @default.
- W2804383336 created "2018-06-01" @default.
- W2804383336 creator A5042914606 @default.
- W2804383336 creator A5076324582 @default.
- W2804383336 date "2018-03-27" @default.
- W2804383336 modified "2023-10-16" @default.
- W2804383336 title "FOLFIRI plus panitumumab in the treatment of wild-type KRAS and wild-type NRAS metastatic colorectal cancer" @default.
- W2804383336 cites W17456534 @default.
- W2804383336 cites W1965195516 @default.
- W2804383336 cites W1975747597 @default.
- W2804383336 cites W1976803095 @default.
- W2804383336 cites W1988501633 @default.
- W2804383336 cites W1993874871 @default.
- W2804383336 cites W2005348280 @default.
- W2804383336 cites W2012006000 @default.
- W2804383336 cites W2015132197 @default.
- W2804383336 cites W2030773607 @default.
- W2804383336 cites W2085633477 @default.
- W2804383336 cites W2102361940 @default.
- W2804383336 cites W2108235590 @default.
- W2804383336 cites W2112570485 @default.
- W2804383336 cites W2121883222 @default.
- W2804383336 cites W2123548341 @default.
- W2804383336 cites W2125877119 @default.
- W2804383336 cites W2132754339 @default.
- W2804383336 cites W2159179344 @default.
- W2804383336 cites W2162247266 @default.
- W2804383336 cites W2203767631 @default.
- W2804383336 cites W2311452740 @default.
- W2804383336 cites W2471862611 @default.
- W2804383336 cites W2529551829 @default.
- W2804383336 cites W2531319683 @default.
- W2804383336 cites W2536838353 @default.
- W2804383336 cites W2558788971 @default.
- W2804383336 cites W2765355075 @default.
- W2804383336 cites W2790425957 @default.
- W2804383336 doi "https://doi.org/10.1186/s12957-018-1359-9" @default.
- W2804383336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5870197" @default.
- W2804383336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29587749" @default.
- W2804383336 hasPublicationYear "2018" @default.
- W2804383336 type Work @default.
- W2804383336 sameAs 2804383336 @default.
- W2804383336 citedByCount "4" @default.
- W2804383336 countsByYear W28043833362020 @default.
- W2804383336 countsByYear W28043833362021 @default.
- W2804383336 countsByYear W28043833362022 @default.
- W2804383336 countsByYear W28043833362023 @default.
- W2804383336 crossrefType "journal-article" @default.
- W2804383336 hasAuthorship W2804383336A5042914606 @default.
- W2804383336 hasAuthorship W2804383336A5076324582 @default.
- W2804383336 hasBestOaLocation W28043833361 @default.
- W2804383336 hasConcept C121608353 @default.
- W2804383336 hasConcept C126322002 @default.
- W2804383336 hasConcept C143998085 @default.
- W2804383336 hasConcept C21790070 @default.
- W2804383336 hasConcept C2776705615 @default.
- W2804383336 hasConcept C2778332735 @default.
- W2804383336 hasConcept C2779804826 @default.
- W2804383336 hasConcept C2779998722 @default.
- W2804383336 hasConcept C2780140570 @default.
- W2804383336 hasConcept C2780259306 @default.
- W2804383336 hasConcept C2781187634 @default.
- W2804383336 hasConcept C526805850 @default.
- W2804383336 hasConcept C71924100 @default.
- W2804383336 hasConceptScore W2804383336C121608353 @default.
- W2804383336 hasConceptScore W2804383336C126322002 @default.
- W2804383336 hasConceptScore W2804383336C143998085 @default.
- W2804383336 hasConceptScore W2804383336C21790070 @default.
- W2804383336 hasConceptScore W2804383336C2776705615 @default.
- W2804383336 hasConceptScore W2804383336C2778332735 @default.
- W2804383336 hasConceptScore W2804383336C2779804826 @default.
- W2804383336 hasConceptScore W2804383336C2779998722 @default.
- W2804383336 hasConceptScore W2804383336C2780140570 @default.
- W2804383336 hasConceptScore W2804383336C2780259306 @default.
- W2804383336 hasConceptScore W2804383336C2781187634 @default.
- W2804383336 hasConceptScore W2804383336C526805850 @default.
- W2804383336 hasConceptScore W2804383336C71924100 @default.
- W2804383336 hasIssue "1" @default.
- W2804383336 hasLocation W28043833361 @default.
- W2804383336 hasLocation W28043833362 @default.
- W2804383336 hasLocation W28043833363 @default.
- W2804383336 hasLocation W28043833364 @default.
- W2804383336 hasLocation W28043833365 @default.
- W2804383336 hasOpenAccess W2804383336 @default.
- W2804383336 hasPrimaryLocation W28043833361 @default.
- W2804383336 hasRelatedWork W2069707939 @default.
- W2804383336 hasRelatedWork W2071471252 @default.
- W2804383336 hasRelatedWork W2114531659 @default.
- W2804383336 hasRelatedWork W2133549424 @default.
- W2804383336 hasRelatedWork W2164674436 @default.
- W2804383336 hasRelatedWork W2508443409 @default.
- W2804383336 hasRelatedWork W2617055067 @default.
- W2804383336 hasRelatedWork W2804383336 @default.
- W2804383336 hasRelatedWork W2892376819 @default.
- W2804383336 hasRelatedWork W3000288349 @default.
- W2804383336 hasVolume "16" @default.
- W2804383336 isParatext "false" @default.
- W2804383336 isRetracted "false" @default.
- W2804383336 magId "2804383336" @default.
- W2804383336 workType "article" @default.