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• W2804384575 abstract "Research has demonstrated that the high capacity requirements of the heart are satisfied by a preference for oxidation of fatty acids. However, it is well known that a stressed heart, as in pathological hypertrophy, deviates from its inherent profile and relies heavily on glucose metabolism, primarily achieved by an acceleration in glycolysis. Moreover, it has been suggested that the chronically lipid overloaded heart augments fatty acid oxidation and triglyceride synthesis to an even greater degree and, thus, develops a lipotoxic phenotype. In comparison, classic studies in exercise physiology have provided a basis for the acute metabolic changes that occur during physical activity. During an acute bout of exercise, whole body glucose metabolism increases proportionately to intensity while fatty acid metabolism gradually increases throughout the duration of activity, particularly during moderate intensity. However, the studies in chronic exercise training are primarily limited to metabolic adaptations in skeletal muscle or to the mechanisms that govern physiological signaling pathways in the heart. Therefore, the purpose of this review is to discuss the precise changes that chronic exercise training elicits on cardiac metabolism, particularly on substrate utilization. Although conflicting data exists, a pattern of enhanced fatty oxidation and normalization of glycolysis emerges, which may be a therapeutic strategy to prevent or regress the metabolic phenotype of the hypertrophied heart. This review also expands on the metabolic adaptations that chronic exercise training elicits in amino acid and ketone body metabolism, which have become of increased interest recently. Lastly, challenges with exercise training studies, which could relate to several variables including model, training modality, and metabolic parameter assessed, are examined." @default.
• W2804384575 created "2018-06-01" @default.
• W2804384575 creator A5009482019 @default.
• W2804384575 date "2018-06-07" @default.
• W2804384575 modified "2023-10-16" @default.
• W2804384575 title "An “Exercise” in Cardiac Metabolism" @default.
• W2804384575 cites W1137470125 @default.
• W2804384575 cites W1527142920 @default.
• W2804384575 cites W1597116068 @default.
• W2804384575 cites W1697389429 @default.
• W2804384575 cites W1787183867 @default.
• W2804384575 cites W1858477058 @default.
• W2804384575 cites W1858532791 @default.
• W2804384575 cites W1876097986 @default.
• W2804384575 cites W1947201748 @default.
• W2804384575 cites W1948436988 @default.
• W2804384575 cites W1965409601 @default.
• W2804384575 cites W1966907771 @default.
• W2804384575 cites W1967405452 @default.
• W2804384575 cites W1968550558 @default.
• W2804384575 cites W1969388950 @default.
• W2804384575 cites W1971932655 @default.
• W2804384575 cites W1977225783 @default.
• W2804384575 cites W1982055384 @default.
• W2804384575 cites W1983459372 @default.
• W2804384575 cites W1992290272 @default.
• W2804384575 cites W1995381409 @default.
• W2804384575 cites W1997997206 @default.
• W2804384575 cites W2000364699 @default.
• W2804384575 cites W2010258469 @default.
• W2804384575 cites W2010620727 @default.
• W2804384575 cites W2017757794 @default.
• W2804384575 cites W2021017483 @default.
• W2804384575 cites W2022143285 @default.
• W2804384575 cites W2024508157 @default.
• W2804384575 cites W2025800616 @default.
• W2804384575 cites W2027999355 @default.
• W2804384575 cites W2031446306 @default.
• W2804384575 cites W2034426121 @default.
• W2804384575 cites W2058737662 @default.
• W2804384575 cites W2063594418 @default.
• W2804384575 cites W2064018881 @default.
• W2804384575 cites W2065094477 @default.
• W2804384575 cites W2069697940 @default.
• W2804384575 cites W2071878387 @default.
• W2804384575 cites W2077948002 @default.
• W2804384575 cites W2084104194 @default.
• W2804384575 cites W2085557310 @default.
• W2804384575 cites W2089901353 @default.
• W2804384575 cites W2092211000 @default.
• W2804384575 cites W2093181249 @default.
• W2804384575 cites W2096843679 @default.
• W2804384575 cites W2098372964 @default.
• W2804384575 cites W2099783126 @default.
• W2804384575 cites W2099988884 @default.
• W2804384575 cites W2100810368 @default.
• W2804384575 cites W2105333866 @default.
• W2804384575 cites W2107134643 @default.
• W2804384575 cites W2113624156 @default.
• W2804384575 cites W2114538920 @default.
• W2804384575 cites W2116298701 @default.
• W2804384575 cites W2118938798 @default.
• W2804384575 cites W2119029041 @default.
• W2804384575 cites W2119792920 @default.
• W2804384575 cites W2120362829 @default.
• W2804384575 cites W2121073264 @default.
• W2804384575 cites W2123276271 @default.
• W2804384575 cites W2124112181 @default.
• W2804384575 cites W2125599236 @default.
• W2804384575 cites W2127312328 @default.
• W2804384575 cites W2127367556 @default.
• W2804384575 cites W2127620022 @default.
• W2804384575 cites W2127661519 @default.
• W2804384575 cites W2128606426 @default.
• W2804384575 cites W2129700082 @default.
• W2804384575 cites W2130928713 @default.
• W2804384575 cites W2131029957 @default.
• W2804384575 cites W2134158244 @default.
• W2804384575 cites W2134256354 @default.
• W2804384575 cites W2135636894 @default.
• W2804384575 cites W2137660505 @default.
• W2804384575 cites W2137689126 @default.
• W2804384575 cites W2138367727 @default.
• W2804384575 cites W2139425458 @default.
• W2804384575 cites W2139535443 @default.
• W2804384575 cites W2140310944 @default.
• W2804384575 cites W2142064939 @default.
• W2804384575 cites W2144730842 @default.
• W2804384575 cites W2150018011 @default.
• W2804384575 cites W2152063942 @default.
• W2804384575 cites W2152794292 @default.
• W2804384575 cites W2153106405 @default.
• W2804384575 cites W2153819921 @default.
• W2804384575 cites W2154202654 @default.
• W2804384575 cites W2154370711 @default.
• W2804384575 cites W2156565014 @default.
• W2804384575 cites W2159005026 @default.
• W2804384575 cites W2159524775 @default.
• W2804384575 cites W2159745709 @default.
• W2804384575 cites W2160656780 @default.

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