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- W2804402992 abstract "Metallopeptidases cleave polypeptides bound in the active-site cleft of catalytic domains through a general base/acid mechanism. This involves a solvent molecule bound to a catalytic zinc and general regulation of the mechanism through zymogen-based latency. Sixty reported structures from 11 metallopeptidase families reveal that prosegments, mostly N-terminal of the catalytic domain, block the cleft regardless of their size. Prosegments may be peptides (5-14 residues), which are only structured within the zymogens, or large moieties (<227 residues) of one or two folded domains. While some prosegments globally shield the catalytic domain through a few contacts, others specifically run across the cleft in the same or opposite direction as a substrate, making numerous interactions. Some prosegments block the zinc by replacing the solvent with particular side chains, while others use terminal α-amino or carboxylate groups. Overall, metallopeptidase zymogens employ disparate mechanisms that diverge even within families, which supports that latency is less conserved than catalysis." @default.
- W2804402992 created "2018-06-01" @default.
- W2804402992 creator A5023079125 @default.
- W2804402992 creator A5036848468 @default.
- W2804402992 creator A5069598229 @default.
- W2804402992 creator A5088089769 @default.
- W2804402992 date "2018-05-18" @default.
- W2804402992 modified "2023-10-17" @default.
- W2804402992 title "Multiple Architectures and Mechanisms of Latency in Metallopeptidase Zymogens" @default.
- W2804402992 cites W1437204455 @default.
- W2804402992 cites W1526493787 @default.
- W2804402992 cites W1570270309 @default.
- W2804402992 cites W1582745181 @default.
- W2804402992 cites W1607581180 @default.
- W2804402992 cites W1643930043 @default.
- W2804402992 cites W168286673 @default.
- W2804402992 cites W1780900118 @default.
- W2804402992 cites W1953569147 @default.
- W2804402992 cites W1960565397 @default.
- W2804402992 cites W1963661035 @default.
- W2804402992 cites W1964428785 @default.
- W2804402992 cites W1968539554 @default.
- W2804402992 cites W1970044331 @default.
- W2804402992 cites W1972513376 @default.
- W2804402992 cites W1976259855 @default.
- W2804402992 cites W1978053309 @default.
- W2804402992 cites W1979576286 @default.
- W2804402992 cites W1980996405 @default.
- W2804402992 cites W1981446882 @default.
- W2804402992 cites W1984319347 @default.
- W2804402992 cites W1984575671 @default.
- W2804402992 cites W1985469117 @default.
- W2804402992 cites W1988371431 @default.
- W2804402992 cites W1988782970 @default.
- W2804402992 cites W1991068889 @default.
- W2804402992 cites W2000206128 @default.
- W2804402992 cites W2001142234 @default.
- W2804402992 cites W2002771508 @default.
- W2804402992 cites W2004417740 @default.
- W2804402992 cites W2004485621 @default.
- W2804402992 cites W2007001778 @default.
- W2804402992 cites W2011224338 @default.
- W2804402992 cites W2017306282 @default.
- W2804402992 cites W2018204206 @default.
- W2804402992 cites W2018209674 @default.
- W2804402992 cites W2018368731 @default.
- W2804402992 cites W2019838731 @default.
- W2804402992 cites W2020406384 @default.
- W2804402992 cites W2021724642 @default.
- W2804402992 cites W2023626030 @default.
- W2804402992 cites W2029196705 @default.
- W2804402992 cites W2029743552 @default.
- W2804402992 cites W2029876202 @default.
- W2804402992 cites W2031582854 @default.
- W2804402992 cites W2032452880 @default.
- W2804402992 cites W2035143124 @default.
- W2804402992 cites W2035567217 @default.
- W2804402992 cites W2043453048 @default.
- W2804402992 cites W2044503036 @default.
- W2804402992 cites W2044797251 @default.
- W2804402992 cites W2047555806 @default.
- W2804402992 cites W2049144105 @default.
- W2804402992 cites W2050023553 @default.
- W2804402992 cites W2051462955 @default.
- W2804402992 cites W2055580270 @default.
- W2804402992 cites W2056531111 @default.
- W2804402992 cites W2057200339 @default.
- W2804402992 cites W2058197352 @default.
- W2804402992 cites W2059919196 @default.
- W2804402992 cites W2061220971 @default.
- W2804402992 cites W2068959407 @default.
- W2804402992 cites W2069508712 @default.
- W2804402992 cites W2071430019 @default.
- W2804402992 cites W2073607085 @default.
- W2804402992 cites W2078301833 @default.
- W2804402992 cites W2080231545 @default.
- W2804402992 cites W2083699890 @default.
- W2804402992 cites W2086825339 @default.
- W2804402992 cites W2086985706 @default.
- W2804402992 cites W2087973465 @default.
- W2804402992 cites W2088252409 @default.
- W2804402992 cites W2089719502 @default.
- W2804402992 cites W2090574955 @default.
- W2804402992 cites W2093261162 @default.
- W2804402992 cites W2093987066 @default.
- W2804402992 cites W2099043326 @default.
- W2804402992 cites W2100709266 @default.
- W2804402992 cites W2103222376 @default.
- W2804402992 cites W2106934485 @default.
- W2804402992 cites W2111767366 @default.
- W2804402992 cites W2115869732 @default.
- W2804402992 cites W2116943300 @default.
- W2804402992 cites W2120717049 @default.
- W2804402992 cites W2121040393 @default.
- W2804402992 cites W2122572489 @default.
- W2804402992 cites W2123565040 @default.
- W2804402992 cites W2127664366 @default.
- W2804402992 cites W2127857604 @default.